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DRUG DELIVERY

Fluid Physics and Transport Phenomena in the Human Brain Laboratory for Product and Process Design , Director A. A. LINNINGER College of Engineering, University of Illinois, Chicago, IL, 60607, U.S.A. Grant Support: NSF, Susman and Asher Foundation. Computer Simulation. Live patient MRI.

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DRUG DELIVERY

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  1. Fluid Physics and Transport Phenomena in the Human Brain Laboratory for Product and Process Design, Director A. A. LINNINGER College of Engineering, University of Illinois, Chicago, IL, 60607, U.S.A. Grant Support: NSF, Susman and Asher Foundation Computer Simulation Live patient MRI HYDROCEPHALUS DRUG DELIVERY Catheter Cortex TECHNICAL APPROACH: MOVING GRID CODE Post – Processing Solvers MR Imaging Grid Generation Image Reconstruction Novel Moving Grid Code + FLUENT 3-D model of the ventricular system and half of the subarachnoid space. 3-D model of the solid brain (white and gray matter). Velocity magnitude (m/sec) • Problem Statement • Prediction of large deformations of the brain parenchyma based on Fluid-Structure Interaction modeling. • Coupling of the brain parenchyma, vascular and ventricular system in the human brain. • Motivation • The therapeutic approach for hydrocephalus treatment is very brutal (shunting) and many revisions are needed. • Ultimate goal: precise model of human brain dynamics to design treatments without in vivo test. • Key Achievements • 3D geometric reconstruction of patient-specific brain dimensions based on MRI data • 3D patient-specific dynamic analysis of CSF flow in the human brain • Future Goals • Optimal Drug Delivery to the Human Brain. • Feedback control systems to better treat Hydrocephalus. • Data from Magnetic Resonance Imaging. • Use of MRI reconstruction tools for generation of 3D patient specific brain geometry. • Introduction of the geometry to Finite Volumes or Finite Elements advanced solvers. • Post processing of the obtained results.

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