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Drug Delivery Chip

Drug Delivery Chip. Jonathan Ims BME 281 Sec. 1. History of the Drug Delivery. 1964, Folkman demonstrated a silicon rubber pill for low molecular weight drugs. 1970s, Langer expanded on Folkman Polymers that could carry macromolecules

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Drug Delivery Chip

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  1. Drug Delivery Chip Jonathan Ims BME 281 Sec. 1

  2. History of the Drug Delivery • 1964, Folkman demonstrated a silicon rubber pill for low molecular weight drugs. • 1970s, Langer expanded on Folkman • Polymers that could carry macromolecules • Mid 1990’s the idea of a drug releasing microchip by J. Santini Jr. • J. Santini Jr. went to MIT

  3. Types of Pumps • Mechanical Micro Pumps • Need a physical actuator • Non-mechanical Micro Pumps • Converts some form of energy into kinetic momentum • Key components • High Flow Rate • Low Voltage (between 5 -12V) • Reliability of the System • Bio-compatibility • Frequency

  4. How the Reservoirs Are Made

  5. Drug Delivery Chip Using Electrolysis

  6. Characteristics of the Drug Deliver Chip • The width and length of each chip varies but the depth of the chip remains between (0.5mm to 1mm) • 8 reservoirs can be found in an area of 1.77mm by 1.44mm • The reservoirs can hold a total of 200nL

  7. Who are the Drug Delivery Chips Intended For? • Patients with Chronic Disease • Diabetes • Epilepsy • Osteoporosis • etc. • It is not meant to replace prescription pills for common illnesses such as the flu.

  8. Limitations • Surgery • Unwanted Side Effects • Heat • Pressure • pH • Bio-compatibilty • Reservoir size

  9. Future Plans • Increase the efficiency of drug delivery • Self-drug releasing chips • Different types of drug release • Better bio-materials

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