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Nanodiamond Drug Delivery

Austin Ramos Biomedical Engineering, URI BME 281. Nanodiamond Drug Delivery. Nanodiamonds. Nanoparticles that are less than 100 nm in diameter (1) Nanodiamonds are useful Biocompatibility Functional versatility Unique surface electrostatics Drug delivery Bypassing chemoresistance

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Nanodiamond Drug Delivery

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  1. Austin Ramos Biomedical Engineering, URI BME 281 Nanodiamond Drug Delivery

  2. Nanodiamonds • Nanoparticles that are less than 100 nm in diameter (1) • Nanodiamonds are useful • Biocompatibility • Functional versatility • Unique surface electrostatics • Drug delivery • Bypassing chemoresistance • Controlled delivery • Intracellular tracking (2) http://www.itc-inc.org/nanodiamond.html

  3. Chemotherapy • Treating cancer with chemical substances namely chemotherapeutic agents like Paclitaxel (PTX) • Many side effects of Chemotherapy are caused cytotoxic drugs that kill rapidly dividing cells in the body whether or not they are cancerous (3) • Bone Marrow • Hair follicles • Digestive tract

  4. Drug Delivery • A nanodiamond drug delivery system was built using nanodiamonds 2-8nm in diameter • Small molecule drugs and nucleic acids are bound to the surface of the NDs and delivered with better efficacy (2) • Nanodiamonds are being tested for their ability to deliver chemotherapeutic agents

  5. Drug Delivery • PTX is attached to the nanodiamonds through fluorescently labeled oligonucleotide strands in addition to anti-EGFR monoclonal antibodies • Anti-EGFR antibodies improve delivery and keep the drug inside the cancer cell (2) (2)

  6. Experiment • Two breast cancer cells MCF7 and MDA-MB-231 were used and tested in vitro • Free PTX • PTX-DNA@ND (untargeted PTX on ND) • PTX-DNA/mAb@ND (targeted PTX on ND) • When compared with free PTX the targeted and untargeted improved the effectiveness of the drug significantly • The targeted PTX showed the best results but was not significantly better than the untargeted PTX in MCF7 cells • In MDA-MB-231 cells the targeted PTX was nearly twice as effective as the untargeted PTX (2)

  7. Conclusion • Nanodiamonds could be a very effective drug delivery system according to these results • NDs are able to significantly increase the efficacy of • Nanodiamonds could also be used for imaging and diagnostics if they are proven to be safe and effective enough

  8. Questions • Works Cited 1.) Jong, De, and Paul JA Borm. "Drug Delivery and Nanoparticles: Applications and Hazards."  International Journal of Nanomedicine IJN(2008): 133-49.  Pubmed. Web. 2.) Zhang, Xue-Qing et.al. "Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging, and Enhanced Chemotherapeutic Efficacy."  Adv. Mater. Advanced Materials  23.41 (2011): 4770-775.Google Scholar. Web. 29 Sept. 2015. 3.)"Chemotherapy." Wikipedia. 19 Sept. 2015. Web. 04 Oct. 2015. <https://en.wikipedia.org/wiki/Chemotherapy>. http://www.itc-inc.org/nanodiamond.html

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