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Uterine Cancer. Endometrial (or uterine) cancer will account for 50,000 new cases and 8200 deaths in the United States in 2013. Two genetic disorders are associated with abnormal genes – Lynch syndrome and Cowden syndrome. Lynch syndrome accounts for 2% of all uterine cancers.
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Uterine Cancer • Endometrial (or uterine) cancer will account for 50,000 new cases and 8200 deaths in the United States in 2013. • Two genetic disorders are associated with abnormal genes – Lynch syndrome and Cowden syndrome. Lynch syndrome accounts for 2% of all uterine cancers. • In Lynch syndrome the risk of uterine cancer by age 70 is 50% (range 25% to 60%) compared to 2.7% for the general population. • Average age of onset is 48 • Like colon cancer patients with Lynch, women with Lynch and endometrial cancer have a better prognosis.
The second disorder is Cowden Syndrome. • This is a mutation in the pTEN protein, which is one of the proteins responsible for regulating cell growth. • Clinically, Cowden is not one finding but a constellation of factors that increase the chance of finding this altered gene. • The following is the consensus criteria for the diagnosis:
To check for Cowden syndrome, you will be assessed to see if you meet criteria for a research study offered by the Cleveland Clinic. • If you meet criteria, the Cleveland Clinic has a grant to look for pTEN mutations. • The test is also available through reference labs.
Beyond these two syndromes there are other conditions that can increase your chances for uterine cancer. • Call for an appointment so we can discuss your family history and whether you might be a carrier of one of these genes.
