1 / 8

Factors influencing release

Factors influencing release. size of drug particles. Factors influencing release. rate and extent of disintegration choice and conc’n of disintegrant. Factors influencing release. choice and conc’n of lubricant. compression pressure. Processing Problems. capping, lamination, chipping.

lloyd
Télécharger la présentation

Factors influencing release

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Factors influencing release • size of drug particles

  2. Factors influencing release • rate and extent of disintegration • choice and conc’n of disintegrant

  3. Factors influencing release choice and conc’n of lubricant compression pressure

  4. Processing Problems • capping, lamination, chipping

  5. Processing problems • sticking • mottling • weight and hardness variation

  6. Tablet Evaluation • these tests are mandatory in the US and the procedures are outlined in the USP • dose uniformity • by weight variation • by content • disintegration

  7. Dissolution testing

  8. Unofficial tests mechanical strength • attrition resistance (friability) • fracture resistance • porosity

More Related