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Senior Design P09052 Molecular Imaging System Upgrade

Senior Design P09052 Molecular Imaging System Upgrade. Ben McGee. Brandon Luquette. Patricia Heneka. Dien Nguyen. Aaron Phipps. Project Description.

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Senior Design P09052 Molecular Imaging System Upgrade

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  1. Senior Design P09052 Molecular Imaging System Upgrade Ben McGee Brandon Luquette Patricia Heneka Dien Nguyen Aaron Phipps

  2. Project Description • To develop a research prototype of a clinical system capable of performing depth-resolved optical molecular imaging of a stationary human hand • Integration of QioptiqLinos’s Optigrid with existing Carestream molecular imaging platform. • Prototype must be functional andflexible enough for Carestream to investigate for commercialization

  3. Proposed Modifications Prototype System Existing Platform

  4. Optigrid Functionality  A portion of the OptiGrid at 200x y z x • Motors provide 120o phase shifts and focus • Grid moves on the x-axis 11.11 um to complete a phase change • Improves Clarity • Grid moves 2 mm on the z-axis to focus image • 30 line pair/mm on a 10x10 mm square • Lines spatially modulate the illumination

  5. Design Objective • Projection of the Optigrid at an angle while maintaining focus

  6. Mechanical Design Solution

  7. Implemented Mechanical Design

  8. System Analysis and Calibration • Characterization • Capable of projecting grid at spatial frequencies ranging from 0.8 – 1.4 line pair/mm • Calibration • Developed a system specific procedure to provide repeatable phase movements • Processing • Depth discrimination proof of concept using depth of modulation analysis

  9. System Characterization .8 line pair/mm • Projected at a 30o angle • Steepest angle capable of the system • The system was set to a zoom of 40 pixels/mm • Magnified using Computar C mount lens • Different Lenses provide different spatial frequency ranges • Captured with a blue excitation filter and a green emission filter 1.4 line pair/mm

  10. Calibration • Coarse Calibration • Capture images in a general range of 30, 55 and 90 V • Calculate phase at each point • Determine approximate voltages for 120ophase shifts.

  11. Demodulation • Images are combined to eliminate the projected frequency using • Incorrectly phase shifted images have residual lines

  12. Processing • Phase shifted images were captured of the phantom block • Fluorescent sheets were inserted between polycarbonate sheets • The block was imaged at two spatial frequencies

  13. Depth Discrimination

  14. Depth Discrimination • Squared error away from the mean at each point is used to evaluate the depth at each point.

  15. Recommendations • Projection Angle • A shorter rail will result in a steeper projection angle which would reduce distortion • Automation • The calibration process is very time consuming and prone to human error. • Timing is very critical to achieving repeatable phase shifts in the Optigrid. • Calibration Procedure Modifications • Warm up routine • Increase the number of phase shifts

  16. Thanks! • Dr. Gilbert Feke • Linda Antos • Dr. Daniel Phillips • Dr. Maria Helguera • Carestream Health • Qioptiq Linos Imaging Solutions

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