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V PARP (PARP-4) : a Vault particle-associated poly (ADP-ribose) polymerase

IHRP. IHRP. BRCT. 547. MVP-BD. NLS. (29%). 1 94. 435. 488. 563. 616-706. 877- 919. 1196. 1562-1724. Anti VPARP. Anti b -tubulin. V PARP (PARP-4) : a Vault particle-associated poly (ADP-ribose) polymerase. • Size : 193 kDa •  Chromosomal Location : 13 q11

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V PARP (PARP-4) : a Vault particle-associated poly (ADP-ribose) polymerase

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  1. IHRP IHRP BRCT 547 MVP-BD NLS (29%) 1 94 435 488 563 616-706 877- 919 1196 1562-1724 Anti VPARP Anti b-tubulin V PARP (PARP-4) : a Vault particle-associated poly (ADP-ribose) polymerase • Size : 193 kDa • Chromosomal Location : 13 q11 • Subcellular location : Vault particles, nuclear spindle, nuclear pores, nucleolus • Activity : poly ADP-ribosylation of MVP (major Vault protein) Vault particles are ribonucleoparticles of 13 MDa (34 x 60 nm) composed of: (i) a small RNA and (ii) three proteins of 100 (MVP), 193 (VPARP) and 240 kDa (TEP1, telomerase associated) in size. Vaults may have a cytoplasm-nucleus transport function Vault particle Kickhoefer et al. (1999) J. Cell. Sci. 146, 917 - 928

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