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Sodium Disorders

Serum Osmolarity. A quantity that approximates serum electrolyte concentration.Serum Osmolarity = 280-300 mOsm/kgH202X[Na ] Glucose/18 Bun/2.8* Difference between calculated and measured osmolarity should agree within 10 or Pseudohyponatremia True Serum Osmolarity = [ Total

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Sodium Disorders

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    1. Sodium Disorders Hyponatremia and Hypernatremia

    2. Serum Osmolarity A quantity that approximates serum electrolyte concentration. Serum Osmolarity = 280-300 mOsm/kgH20 2X[Na+] + Glucose/18 +Bun/2.8 * Difference between calculated and measured osmolarity should agree within 10 or Pseudohyponatremia True Serum Osmolarity = [ Total Cations + Total Anions]

    3. Effective vs Ineffective Osmoles Difference is determined by the substances ability to be freely permeable across cell membranes and as a result cause fluid to shift between compartments.

    4. Effective Ineffective Sodium Glucose Mannitol Membrane Impermeant Cause change or shift in fluid distribution between ICF and ECF Ethanol Urea Membrane permeant Cause no change or shift in fluid distribution between ICF and ECF

    5. Osmolarity Regulation ICF Osm. = ECF Osm. Interstitial Osm = Serum Osm. Hypothalamus is the serum osmostat. It stimulates thirst and ADH secretion. Primary Defense for Osmolarity = Thirst Primary Defense for Osmolarity = Renal excretion of water via ADH effect

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