1 / 6

MOUTH

Lingual Lipase. FFA + DAGs (miniscule amounts). Lipids: Triacylglycerols. 1a. Cholesterol esters Phospholipids. Lingual Lipase ("acid-stable"). FFA + DAGs (small amounts). 1b. MOUTH. Triacylglycerols. STOMACH. STEP 1: Digestion in the Mouth and Stomach.

lotus
Télécharger la présentation

MOUTH

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Lingual Lipase FFA + DAGs (miniscule amounts) Lipids: Triacylglycerols 1a Cholesterol esters Phospholipids Lingual Lipase ("acid-stable") FFA + DAGs (small amounts) 1b MOUTH Triacylglycerols STOMACH STEP 1: Digestion in the Mouth and Stomach Courtesy of Dr. Marc Tischler

  2. CCK-PZ stimulates secretion from stomach FFA Trypsinogen Pancreatic lipase Pancreatic Procolipase Pancreatic esterase Pancreatic ProPLA2 EXOCRINE PANCREAS trypsinogen, procolipase, lipase, esterase, HCO3-, proPLA2 Endocrine cell Cholecystokin-pancreozymin (CCK-PZ) via bloodstream Bile Salt storage SMALL INTESTINE duodenum/jejunum Bile Acid Synthesis Conjuga- tionLIVER GALL BLADDER CCK-PZ causes contraction STEP 2: Enzymatic Digestion in the Duodenum/Jejunum – secretion of zymogens/bile salts Courtesy of Dr. Marc Tischler

  3. LIVER Enterohepatic circulation of bile acids FFA, 2MG 3b cholesterol lysolecithin vitamin A 3b Portal vein Released bile acids Short/medium chain FFA Reabsorbed by ileum Capillaries SMALL INTESTINE duodenum/jejunum Mixed Micelles 4 STEP 3b: Bile Acid Recycling STEP 4: Lipid Absorption Courtesy of Dr. Marc Tischler

  4. 6b To lacteals and thoracic duct (lymphatic system) B48 Chylomicron vitamins D, E, K 6a Coating with apolipoprotein (with TTP) Cholesterol ester Phospholipid Triacyl- glycerol 5 ACAT reesterification FFA, 2MG cholesterol lysolecithin vitamin A SMALL INTESTINE duodenum/jejunum Triacylglycerol transfer protein Acyl CoA: cholesterol acyl transferase STEP 5: Re-esterification STEP 6: Chylomicron Assembly and Export Courtesy of Dr. Marc Tischler

  5. chylomicron interacts with lipoprotein lipase removing FFA Nascent chylo-microns acquire apo CII (C) and E (E) from HDL C E C E C E C E C E C E C E C E C E Lymph system: Chylomicrons to capillaries via lymph INTEST INE non-hepatic tissues ApoB48 aids with chylo-micron assembly LIVER Chylomicrons carry dietary fatty acids to tissues and the remnants take cholesterol to the liver

  6. chylomicron interacts with lipoprotein lipase removing FFA Lymph system: INTEST INE chylomicron acquires apo CII (C) and E (E) from HDL C E C E C E C E C E E C E C E E C E C E C E C chylomicron remnants lose CII to HDL E C E E E Liver: apo E receptor takes up remnants to deliver cholesterol non-hepatic tissues ApoB48 LIVER Chylomicrons carry dietary fatty acids to tissues and the remnants take cholesterol to the liver Courtesy of Dr. Marc Tischler

More Related