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This report analyzes the annual event rates associated with various critical outcomes, including loss of Complete Hematologic Response (CHR), loss of Major Cytogenetic Response (MCyR), and occurrences of acute progression or biochemical changes (AP/BC) leading to patient mortality during treatment. Data spans the first to sixth years of therapy, revealing a trend of declining event rates. Understanding these metrics is crucial for evaluating long-term treatment efficacy and patient prognosis. Continuous monitoring of these outcomes will aid in optimizing future therapeutic protocols.
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Declining Annual Event Rates *Including loss of CHR, loss of MCyR, AP/BC, or death during treatment 8 7.5 7 6 4.8 Event* 5 AP/BC % annual rates 4 3.3 2.8 3 1.6 2 1.5 1.5 0.9 0.8 1 0.5 0.4 0 0 Year 1st 2nd 3rd 4th 5th 6th