1 / 8

Atypical ductal hyperplasia

Atypical ductal hyperplasia. “ A diagnosis of ADH should not be made unless a diagnosis of low grade DCIS is being seriously considered ” WHO Breast 2012 A matter of quantity Architecture: cribriform spaces, micropapillae (bulbous), rigid bars

lucita
Télécharger la présentation

Atypical ductal hyperplasia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Atypical ductal hyperplasia • “A diagnosis of ADH should not be made unless a diagnosis of low grade DCIS is being seriously considered” WHO Breast 2012 • A matter of quantity • Architecture: cribriform spaces, micropapillae (bulbous), rigid bars • Cytology: ‘clonal’, monotonous, mild nuclear atypia, enlarged, nucleoli, distinct cell borders. Same as LG-DCIS

  2. ADH/DCIS • When does ADH become DCIS? • A matter of quantity. • Criteria still vary and are not standardized • WHO states: > 2 mm and/or completely involving at least two duct spaces. • Any intraductal proliferation with moderate-high grade nuclear features = DCIS (no size criteria). • Sometimes ADH and UDH co-exist

  3. IHC • IHC : UDH vs ADH/DCIS • CK5/6 and ER • Caveat: Not helpful in columnar cell change or apocrine change.

  4. Practical point • If a core biopsy shows borderline features of ADH/DCIS, be conservative and call it ‘at least ADH’ • An upgrade rate to DCIS on excision is well known and accepted. • Harder to explain DCIS, limited to the core.

  5. ER CK5/6

More Related