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Comprehensive QTL Analysis of Family Structures with Offspring Variations

This study examines a total of 872 biological pairs derived from 200 families with 2 offspring and 224 families with 3 offspring. In the analysis, we focus on the relationships among pairs and trio structures, calculating outcomes such as chi-square values for complete families and pairs. The quantitative trait locus (QTL) analysis reveals genetic contributions, with additive effects (A=40%), environmental influences (E=30%), and non-additive genetic effects (Q=10%). The findings enhance our understanding of familial genetic structures and their implications in hereditary studies.

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Comprehensive QTL Analysis of Family Structures with Offspring Variations

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  1. Pairs / trio’s 200 families with 2 offspring, 224 with 3 offspring 200 pairs & 224 trios =200 + 3*224= 200 + 672 = 872 pairs (and is 400 + 672 = 1072 subjects) QTL analysis (A = 40%, E = 30%, Q = 10%) Analysis of 424 complete families: chi-square = 2.295 (df =1) Analysis of 872 pairs: chi-square = 2.293

  2. Pairs / trio’s; all possible pairs vs whole family One family with 2 members generates 1 pair One family with 2 members generates 3 pairs One family with 4 members generates 6 pairs Etc.. In Mx you can easily model multiple sibs in a fami

  3. Pairs / trio’s; all possible pairs vs whole family 200 families with 2 offspring, 224 with 3 offspring 200 pairs & 224 trios =200 + 3*224= 200 + 672 = 872 pairs (and is 400 + 672 = 1072 subjects) QTL analysis (A = 40%, E = 30%, Q = 10%) Analysis of 424 complete families: chi-square = 2.295 (df =1) Analysis of 872 pairs: chi-square = 2.293

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