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Wnt Signaling Pathways: Quiescent and Activated Cells in Relation to β-Catenin Dynamics

This overview delves into the Wnt signaling pathways in both quiescent and activated cells, highlighting the roles of key proteins such as Frizzled, E-cadherin, β-catenin, P-Slimb, α-catenin, and GSK3β. The description of quiescent cells involves a detailed examination of how β-catenin is regulated by conductin/axin and APC, leading to specific LEF/TCF target genes. In contrast, activated cells showcase a different mechanism involving disheveled (Dsh) and the subsequent effects of APC loss, further impacting E-cadherin and target gene expression.

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Wnt Signaling Pathways: Quiescent and Activated Cells in Relation to β-Catenin Dynamics

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  1. Quiescent Cells: frizzled E-cadherin -catenin P slimb -catenin GSK3 -catenin conductin/axin APC LEF/ TCF Target Genes

  2. wnt Activated Cells: frizzled dsh E-cadherin -catenin P slimb -catenin GSK3 -catenin conductin/axin APC LEF/ TCF Target Genes

  3. Loss of APC: frizzled E-cadherin -catenin P slimb -catenin GSK3 -catenin conductin/axin APC LEF/ TCF Target Genes

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