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Eukaryotic Cell Cycle

Eukaryotic Cell Cycle. Microscopic view of Cell Division. Interphase: Period between Two M Phases. ,yjdl,utde.jufr. Cytokinesis. Mitosis. DNA Replication. G1 checkpoint Start 1 Is cell big enough? Is environment favorable? G2 checkpoint Enter M1 Is DNA replicated?

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Eukaryotic Cell Cycle

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  1. Eukaryotic Cell Cycle

  2. Microscopic view of Cell Division Interphase: Period between Two M Phases.

  3. ,yjdl,utde.jufr Cytokinesis Mitosis DNA Replication

  4. G1 checkpoint • Start 1 • Is cell big enough? • Is environment favorable? • G2 checkpoint • Enter M1 • Is DNA replicated? • Is environment favorable? • Is cell big enough? • Metaphase checkpoint • Exit from M1 • Are all chromosomes aligned on spindle?

  5. Core of Cell Cycle control

  6. Oocyte growth and egg cleavage in X. laevis

  7. Xenopus egg maturation and activation

  8. Assaying for MPF

  9. Cell Fusion

  10. Cell Fusion

  11. Cell Fusion

  12. Rise and Fall of MPF and cyclins

  13. Evidence for the Re-Replication Block

  14. S.pombe cdc2 mutants (Wild-type) (Cannot enter Mitosis) (Enters mitosis Early)

  15. Regulation of MPF protein kinase activity in S. pombe

  16. Effects of Mutations in cdc25 and wee1

  17. S. cerevisiae Cdc28-cyclin complexes

  18. Mammalian Cdk-cyclin complexes

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