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Squamous cell carcinoma

Squamous cell carcinoma. Note keratin pearls and desmosomes Name some characteristics. Only in smokers Centrally located Hypercalcemia  PTH like substance is made CLUBBING. asthma. Note the thickened BM and SM cells. Bronchoalveolar Carcinoma. Subset of adenocarcinoma

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Squamous cell carcinoma

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  1. Squamous cell carcinoma Note keratin pearls and desmosomes Name some characteristics

  2. Only in smokers • Centrally located • Hypercalcemia  PTH like substance is made • CLUBBING

  3. asthma Note the thickened BM and SM cells

  4. Bronchoalveolar Carcinoma • Subset of adenocarcinoma • Not associated with smoking • Peripheral location • Bronchograms are common • Cough with frothy sputum

  5. Bad sputum sample Shows the normal squamous epithelial cells found in the upper respiratory tract… Contamination of the sample

  6. Squamous cell carcinoma

  7. Small cell carcinoma Note blue cells with high N/C ratio No nucleoli Salt n peppa neuroendocrine cells

  8. Adenocarcinoma Name the characteristics

  9. Mucin • Glands • Peripheral • Most common type of lung CA • Can occur at sites of scars • Clubbing • Most common type of lung CA in non smokers

  10. Charchot-leyden crystals Found in what lung disease?

  11. asthma These are formed from granules of destroyed eosinophils

  12. hamartoma

  13. “discrete tumor of benign tissues in excess or disarray” Cartilage in excess

  14. Smudge cell Ha—were you paying attention in hemonc??

  15. Large cell undifferentiated lung cancer Note that there are no glands, desmosomes, keratin Name some characteristics.

  16. Located most often in the periphery • Ummmm.

  17. Large cell lung cancer

  18. sarcoidosis

  19. Pneumocystis carinii Foamy stuff in alveolar spaces BAL is a good test for PCP

  20. Usual Interstitial Pneumonitis

  21. Patchy regions of interstitial inflammation and fibrosis alternating with normal lung parenchyma • Temporal heterogeneity • What’s the differential?

  22. UIP • Asbetosis • Rheumatic disease • What’s the treatment?

  23. O2 therapy

  24. sarcoidosis

  25. Bacterial pneumonia Diplococci and white cells from sputum sample What are the common bacteria that cause this?

  26. Streptococcus pneumoniae • Staphlococcus aureus • Hemophilus influenze (gram neg) • Klebsiella pneumonia (gram neg) • Pseudomonas aeruginosa

  27. bronchiectasis Purulent debris in lumen Dilated bronchus Def:?

  28. Irreversible dilation of airways caused by inflammatory destruction of airway walls • Most common cause is infection • 2 non-obstructive causes =

  29. Cystic fibrosis • Kartagener’s syndrome • (primary cilia dyskinesia syndrome)

  30. pneumonia Alveolar filling with PMNs

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