PEOPLE COMMUNITY RESOURCES

1. Class III Cell Culture PEOPLE COMMUNITY RESOURCES LOCATION FOR NEW EU INFRASTRUCTURE FOR BIONANOINTERACTIONS AND NANOSAFETY Students from 14 countries majority funds EU internationally 26 companies from around the world Cozzarelli Prize, 2008 FP RESEARCH SFI SRC, EPA, HEA http://www.cbni.eu Centre for BioNano Interactions NeuroNano IANH’

2. 1st reports of Nanotoxicity Protecting the potential for generations to come Potential for radically new therapies Risk, investment and perception of risk Address the great intractable diseases Cross biological barriers, e.g. blood brain barrier

3. Nanoparticles travel into cell via Existing pathways Watson et al. Adv Drug Delivery Rev 2005

4. By Treaty, Parliament and Commission must agree on key policy issues European Parliament Membersback tougher rules for nanotechnology Published: 28 April 2009 The European Parliament backed a report urging the European Commission to revise its stance on nanomaterials. MEPs said all nanomaterials should be considered as new substances. Adopted on April 24 2009 by an overwhelming majority – 391 in favour and 3 against. European Parliament Members Vote for Ban on Nanomaterials: Nanosilver and Carbon Nanotubes June 16, 2010 The Members of the European Union’s (“EU”) Environment Committee (“MEPs”) voted in favor of proposed amendments to the EU’s Restriction of Hazardous Substances Directive, banning the use of nanosilver and long multi-walled carbon nanotubes in electrical and electronic products. Etc. ……Worldwide issues

5. BioNanoInteract now central EU Infrastructure for arena Re-profiled SRC spending to capture emerging opportunities

6. ARRESTED MATTER BUILT DEPTH IN NANO AND MESOSCOPIC PARTICLES Marie Curie Research and Training Network on Dynamical Arrest Arrested Matter – 19 Network Partners Start date – November 2004 Project Duration – 5 years (including a 1 year extension) Coordinator – University College Dublin Partners – -Universita di Napoli -University of Bristol -Institute for Atomic and Molecular Physics -Harvard University -Universitat Freiburg -Universita di Messina -Universite Montpellier II -Universita di Milano -Heinrich-Heine Universitat Dusseldorf -Johannes Gutenberg Universitat Mainz -University of Edinburg -University of Fribourg -Universita di Roma -Massachusetts Institute of Technology -Institut fur Chemie, Karl Franzens Universitaet Graz -Universite du Maine, Centre National Recherche de Scientific -Instituto Nazionale de Fisica Nucleare

7. The distribution of the countries of origin of the ESR and ER are shown here:

8. The distribution of the ESR and ER across the partner nodes is shown here:

9. APPROACHES FROM ARRESTED MATTER FED INTO RADICALLY NEW APPROACHES 40nm COOH-PS NPs MOVIE OF LIVING CELL FROM MICROSCOPE, LEADING TO ‘SIMULATION’

10. SUCCESSES AND FAILURES • Successes: • Many of the young people who took part within the framework became the young leaders of the field- (UCD alone)de Gregorio (Prize), Foffi (Swiss national Prize EPFL, Assistant Prof), Zaccarelli (permanent position Rome, leader!) Cellai (CSET) Many other around EU. • Coherent workshops across whole field (100 young people often) seen as the birth of the modern field in EU (we moved further into biological applications afterwards) • Beginning of real fundamental depth in UCD in soft nanoparticle materials, and merger of experimental data with theory (see cell experiment previously) • Failures: • Not every student succeeded as planned (including some in MC program itself!). • Balance of post docs vs students (my fault) per group was imperfect (all UCD were ESR) • Structure (committees for everything) was made overly complex, and overly heavy in an effort to make transparent and fair in every way-my fault, well intended

11. SOON TO START PARTNER • FP7-PEOPLE-2010-ITN • NanoTOES (Nanotechnology: Training Of Experts in Safety) – 12 Network Partners • Start date – 1st November 2010 • Project Duration – 4 years • Coordinator – University of Salzburg • Partners – • Consiglio Nazionale Delle Ricerche • Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V • University College Dublin • Natural Environment Research Council • Norsk Institutt for Luftforskning • Institut Universitaire Romand De Sante Au Travail • Institute of Experimental Medicine – Hungarian Academy of Sciences • Catalan Institute of Nanotechnology • AvantiCell Science Ltd • Grimm Aerosol Technik Gmbh & Co KG Pesch • Bayer Technology Services GMBH

12. NO ONE CAN SAY HOW TO SUCCEED PERSONAL VIEW Winning as Co ordinator • Win the key step by prior results-even if it is only one key paper, make it the ‘example • Find the best people (who know how to educate young leaders), and ask them early • But not too many (!) • Frame the initial vision yourself, explain it carefully-show each the role they would play • Identify the real need at EU level for such young people trained (eg Infra) • Start early Winning as Partner • If you are senior, easier, if more junior, ask seniors to include you-don’t by shy • Try to be a support centrally in the preparation, and execution-visibility, and experience • Start early