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Factors that can produce gene mutations…

Mutations. Factors that can produce gene mutations…. Mutation : a change in the DNA sequence that is inherited. a) ____________ b) ______________ c) ______________. What happened?. What happened?.

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Factors that can produce gene mutations…

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  1. Mutations Factors that can produce gene mutations… Mutation: a change in the DNA sequence that is inherited a) ____________ b) ______________ c) ______________

  2. What happened? What happened?

  3. ____________ mutation: A mutation that causes the reading frame of codons to change, usually resulting in different amino acids being incorporated into the polypeptide

  4. _________ mutation: A mutation at a specific base pair in the genome

  5. _______________mutation: A mutation that converts a codon from an amino acid into a termination codon – very harmful!

  6. _______________mutation: A mutation that results in the single substitution of one amino acid in the resulting polypeptide

  7. Which one is worse, missense or nonsense? A _________________ mutation results in the termination of the translation, therefore the protein is inactive. A _________________ mutation can be just as harmful, however, there is the slight chance that it would not.

  8. Determine whether or not the following mutations would be harmful. Translate the mRNA sequence into protein to help you decide. The mutation is indicated in red. • AUG UUU UUG CCU UAU CAU CGU • AUG UUU UUG CCU UAC CAU CGU

  9. b) AUG UUU UUG CCU UAU CAU CGU • AUG UUU UUG CCU UAA CAU CGU • c) AUG UUU UUG CCU UAU CAU CGU • AUG UUU CUU GCC UUA UCA UCG U

  10. Prokaryotes _______and circular All regions are coding, except for ________and __________ ___________of operons Eukaryotes _______ and arranged in chromosomes Consists of coding and noncoding regions ___________of operons Key Differences in Genome

  11. Prokaryotes Coupled with ___________ Lack of ________means no excission Eukaryotes Occurs in the __________ Introns excised by ______________ and exons joined together Key Differences in Transcription

  12. Prokaryotes Commence with _______-methionine Ribosome recognizes Shine-Dalarno sequence on mRNA as binding site Ribosomesare _________than in eukaryotes Eukaryotes Commences with methionine Ribosome recognizes 5’ cap on mRNA as binding site Occurs in the cytoplasm Ribosomes are larger than in prokaryotes Key Differences in Translation

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