340 likes | 491 Vues
Molecules In Space:. Diffusible Signals in the Synapse. David Santucci Quantitative Biology Bootcamp 2009. John Heuser. John Heuser. Ca 2+. Synaptotagmin. SNARE Complex. VGCC. Ca 2+. Synaptotagmin. SNARE Complex. VGCC. Ca 2+. Synaptotagmin. SNARE Complex. VGCC. Diffusion.
E N D
Molecules In Space: Diffusible Signals in the Synapse David Santucci Quantitative Biology Bootcamp 2009
Ca2+ Synaptotagmin SNARE Complex VGCC
Ca2+ Synaptotagmin SNARE Complex VGCC
Ca2+ Synaptotagmin SNARE Complex VGCC
flux - concentration distance Fick’s First Law of Diffusion
flux flux concentration - + distance Fick’s Second Law of Diffusion
- flux flux concentration - + distance Fick’s Second Law of Diffusion
global calcium local calcium VGCC
global calcium local calcium VGCC
EGTA BAPTA
EGTA BAPTA
Calcium Cage photolysis Caged Calcium Uncaged Calcium