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Gene Regulation

Gene Regulation. Levels of Regulation. DNA rearrangement Immune System rearranges DNA Bacteria can change DNA in chromosomes Not as common as other methods. Transcriptional Regulation. Regulate RNA polymerase starting transcription Splicing choices can regulate gene expression

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Gene Regulation

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  1. Gene Regulation

  2. Levels of Regulation • DNA rearrangement • Immune System rearranges DNA • Bacteria can change DNA in chromosomes • Not as common as other methods

  3. Transcriptional Regulation • Regulate RNA polymerase starting transcription • Splicing choices can regulate gene expression • MRNA stability – How fast MRNA degrades, can protect it with regulator

  4. Translational Regulation • Wrap up RNA so it cant get to Ribosome • Microrna – 21 base pair sequences interfere with translation of MRNA

  5. Post-Translational Regulation • Activate with enzyme • Mitochondria

  6. Most Important • Transcriptional Regulation is most important • 80% of red blood cells is alpha or betaglobin • Describe Lac Operon in E Coli

  7. E Coli • Bacteria would like glucose to grow on • Glucose ->ATP->Energy • Lactose if it cant find glucose • Uses beta-galactosidase to break down Lactose into glucose • In the presence of Lactose, 10% of proteins will be Beta-gal • Cant keep that level in absence of beta-gal or selection would favor more efficient system • lactose permease allows Lactose to enter cell

  8. Lac Operon Promoter LacZ LacY LacA PLac B-gal Permease Promoter LacI PI Lac Repressor

  9. Cell Function

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