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Improved Industrial Biocatalysts

Improved Industrial Biocatalysts. Rex Williams Nhi Nguyen Randhir Shetty Dr. Ryan Klein Dr. Dhiren Thakker. Enzymes. http://www.genome.gov/glossary/index.cfm?id=58. H. H. Lipase. Lipase in Cell-Free System. NORMAL LIPASE.

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Improved Industrial Biocatalysts

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  1. ImprovedIndustrialBiocatalysts Rex Williams Nhi Nguyen RandhirShetty Dr. Ryan Klein Dr. DhirenThakker

  2. Enzymes http://www.genome.gov/glossary/index.cfm?id=58 H H Lipase

  3. Lipase in Cell-Free System NORMAL LIPASE Animation Courtesy of Dr. Ryan Klein

  4. Enhanced Lipase ENHANCED LIPASE Animation Courtesy of Dr. Ryan Klein

  5. Lipase Applications • Projected global lipase market (2012)- $100 million • Existing markets are stagnant • Current markets are dominated by a small number of manufacturers • Rationale For Biodiesel Application • Rapidly growing industry (CAGR >20%) • Lipases allow use of lower-cost feedstocks “However, in order to compete with diesel fuel and survive in the market, lower-cost feedstocks are preferred, including waste cooking oil (WCO), grease, soapstocks [3-18], since feedstocks costs are about more than 85% of the total cost of biodiesel production” -- Fan & Burton, The Open Fuels & Energy Science Journal, 2009

  6. US Biodiesel Market At $3.2B & Growing At 20% • US 2010 biodiesel market size: $3.2 Billion • Expected YOY consumption growth rate in US is 20% • Chinese commercial enzymatic biodiesel production: 6 million gallons/year pilot plant Source: 2010 Euromonitor International • Current State of the Technology • Reaction chemistry demonstrated in lab • Lipase catalyzed process is emerging in biodiesel industry • International patent filed: PCT/US2008/005486 • US patent applied filed: 12/597,821

  7. Next steps for Enhanced-Lipase Technology MARKET PULL QUANTIFICATION • Quantify potential improvements in process efficiency • Assess state of competing technologies addressing market need • Confirm proof of concept in small-scale biodiesel production • Secure additional IP capturing value for biodiesel application TECHNOLOGY DEVELOPMENT CUSTOMER VALIDATION • Sense customer response to biocatalyst application with different feedstock • Perform quantitative product pricing study to establish willingness to pay LICENSING / JV • Perform cost-benefit analysis between JV & licensing • Assess potential partners for commercial launch.

  8. Acknowledgements • Coaches • Anil Goyal, Ph.D., CLP • OpenDoors Group, LLC • BioLeap, Inc. • Jay Madan • iBiotech, Inc. • Inventors/Advisors • DhirenThakker, Ph.D. • UNC School of Pharmacy • Ryan Klein, Ph.D. • Office of Technology and Development • Peter Liao • Team • Rex L. Williams, Jr. • UNC Department of Genetics • rwilliam@med.unc.edu • Nhi Nguyen • UNC School of Law • npnguyen@email.unc.edu • RandhirShetty • UNC Kenan-Flagler Business School • Randhir_Shetty@kenan-flagler.unc.edu

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