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Metabolic Engineering: Advances, Applications, and Future Prospects in Biotechnology

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This lecture highlights key aspects of nucleotide metabolism, metabolic engineering, and their applications in drug design, diagnostics, and industrial production. It discusses notable research like the engineering of *Escherichia coli* for optimized aromatic metabolite production and insights from the Human Metabolome Project. Emphasis is placed on future possibilities such as creating life from scratch and the role of metabolomics in disease differentiation and response to therapies. Participants can engage through a live Q&A session to explore questions on these topics.

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Metabolic Engineering: Advances, Applications, and Future Prospects in Biotechnology

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Presentation Transcript

  1. Lecture 25 QUESTIONS? Text 37607 Msg: 118916 Question QUESTIONS? Gotohttp://pollev.com/ucibio Enter question

  2. Last class Nucleotide metabolism highlights Metabolism overview

  3. The future Disease phenotype  treatment Drug design & development Protein engineering Industrial applications Diagnostics

  4. Metabolic engineering Engineer a whole pathway? Large scale production? Biosynthesis: - Fuel - Nutraceuticals What else?!?!!

  5. Example of metabolic engineering Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908

  6. Example of metabolic engineering Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908

  7. Example of metabolic engineering Pps Pps* Pps# Control Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908

  8. -Omics = Metabolomics! ENTIRE collection of metabolites! “Metabolome”

  9. Metabolome & drugs Kaddurah-Daouk, Rima, Bruce S. Kristal, and Richard M. Weinshilboum. "Metabolomics: a global biochemical approach to drug response and disease." Annu. Rev. Pharmacol. Toxicol. 48 (2008): 653-683.

  10. Discovering diagnostic markers Kenny, Louise C., et al. "Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning." Metabolomics 1.3 (2005): 227-234.

  11. Differentiating disease conditions Kaddurah-Daouk, Rima, Bruce S. Kristal, and Richard M. Weinshilboum. "Metabolomics: a global biochemical approach to drug response and disease." Annu. Rev. Pharmacol. Toxicol. 48 (2008): 653-683.

  12. The Human Metabolome project

  13. Synthetic biology – “creating” life… “Build” a genome from scratch? What is “minimal” genome?

  14. …and beyond! Protein + metabolic engineering Any compound, any time! “Download” vaccine to personal biofactory?!

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