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Respiratory Physiology: Diffusion Mechanisms in Pulmonary Capillaries

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Explore the intricate processes of diffusion in respiratory physiology, focusing on Fick's Law, blood-gas barrier thickness, and limitations in gas transfer. Dive into concepts like CO-Hb dissociation, diffusion and perfusion dynamics, and measuring diffusing capacity.

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Respiratory Physiology: Diffusion Mechanisms in Pulmonary Capillaries

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Presentation Transcript

  1. Diffusion Lectures on respiratory physiology

  2. Swim bladder of a fish

  3. Fick’s law of diffusion through a tissue sheet

  4. Very thin blood-gas barrier

  5. Electron micrograph of pulmonary capillary

  6. High power view of blood-gas barrier

  7. Fick’s law of diffusion through a tissue sheet

  8. Kinetic theory of gases

  9. Fick’s law of diffusion through a tissue sheet

  10. Diffusion and perfusion limitations

  11. CO-Hb DISSOCIATION CURVE CO SATURATION, % O2 PARTIAL PRESSURE, mm Hg

  12. Diffusion and perfusion limitations

  13. Very thin blood-gas barrier

  14. Thickened blood-gas barrier

  15. Time courses of Po2 in the capillary

  16. Measurement of Diffusing Capacity

  17. Single breath method for DCO

  18. Electron micrograph of pulmonary capillary

  19. Reduced Hb Spectro Photometer 100 Mixing Chamber HBO2 % t 0 0.1 0.2 O2 solution time (sec) Measurement of the rapid reaction of O2 with Hb

  20. The two components of DL

  21. Is the transfer of CO2 ever limited by diffusion?

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