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Mouse Genome Polymorphism Detection Tool for Research Progress Monitoring

This project involves using Ruby on Rails to create a web server that utilizes MySQL to store data on mouse genome polymorphisms. BLAT Pygr and a Python-based tool are employed to display sequencing data for multiple strains. The tool aims to efficiently detect and map polymorphisms.

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Mouse Genome Polymorphism Detection Tool for Research Progress Monitoring

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  1. Detecting Polymorphisms in Mouse Genome Phillip Tao Advisor: Eleazar Eskin Grad Student: Emrah Kostem

  2. Ruby on Rails • Using Ruby on Rails to create web server • MySQL to store data • Display data gathered using BLAT

  3. Pygr • Python based tool for sequencing data • Can compare two or more strains • Tried using to find inversions • Takes too long / too resource intensive

  4. BLAT • Similar in function to Pygr • Significantly less memory intensive • Will be used to find and map polymorphisms

  5. Roadmap • Significantly less progress than expected • Web server mostly functional by January • Winter quarter to map polymorphisms • Spring quarter to use map of polymorphisms and predict phenotype

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