1 / 4

Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms

Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms. Corey Harada Advisor: Eleazar Eskin. Statement of Problem. Single Nucleotide Polymorphism (SNP) Mutation of a single nucleotide in a strand of DNA.

leemcdaniel
Télécharger la présentation

Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms Corey Harada Advisor: Eleazar Eskin

  2. Statement of Problem • Single Nucleotide Polymorphism (SNP) • Mutation of a single nucleotide in a strand of DNA. • Important in pharmaceuticals; affect how things respond to disease. • ~8.27 million SNPs found in classical mouse strains. • We know the locations of the SNPs on the mouse genome, but not what they do.

  3. Goals • Associate SNPs with phenotypic differences in mice. • SNPs in protein coding regions, noncoding regions, or intergenic region. • Develop new algorithms to accomplish the above goal • Difference in scale: previously, only ~140,000 SNPs had been mapped.

  4. Methodology • Organize the SNP data into an online database. • Use Ruby on Rails with MySQL database to construct webserver. • Assisted by graduate student Emrah Kostem.

More Related