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Interphase and M-Phase Chromosomes

Interphase and M-Phase Chromosomes. Condensation of Chromatids. Kinetochore. Pg. 645. Kinetochore. Mitotic Spindle. Centrosome Duplication Cycle. Nuclear Lamina. Pg. 576. Microtubules. Mitotic Spindle. Metaphase. Anaphase. Pg. 641. +. Ub. Ub-Ub-Ub. Protein. Protein. Proteasome.

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Interphase and M-Phase Chromosomes

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  1. Interphase and M-Phase Chromosomes

  2. Condensation of Chromatids

  3. Kinetochore Pg. 645

  4. Kinetochore

  5. Mitotic Spindle

  6. Centrosome Duplication Cycle

  7. Nuclear Lamina

  8. Pg. 576

  9. Microtubules

  10. Mitotic Spindle

  11. Metaphase Anaphase Pg. 641

  12. + Ub Ub-Ub-Ub Protein Protein Proteasome Peptides + Ub Ubiquitin-dependent Protein Degradation APC (Ubiquitin Ligase) Pg. 257

  13. P Start of Anaphase

  14. Anaphase “A” and “B”

  15. Membrane Fusion in Cytokinesis

  16. Cytokinesis

  17. Myosin II - GFP Interphase Telophase Cytokinesis Cytokinesis Cytokinesis G1

  18. Control Points in the Mitotic Cell Cycle Control at the G2/M Transition DNA Replication Control at the G1/S Transition

  19. Cyclin Protein Levels Vary During the Cell Cycle

  20. Cyclin/Cdk Complexes During the Cell Cycle Expression of M-cyclin Gene Ubiquitin-dependent proteolysis Ubiquitin-dependent proteolysis Expression of S-cyclin Gene

  21. Cyclin/Cdk Phosphorylates Rb Protein (RTK) (Ras-MAP Kinase) Activation of “S-Phase Genes”

  22. Cyclin/Cdk Phosphorylates Cdc6 Protein and ORC

  23. Cyclin/Cdk Complexes During the Cell Cycle Expression of M-cyclin Gene Ubiquitin-dependent proteolysis Ubiquitin-dependent proteolysis Expression of S-cyclin Gene

  24. P Cyclin/Cdk Phosphorylates APC M-Cyclin/Cdk

  25. Active APC Inactivating the Cyclin/Cdk Complex

  26. Cell Cycle Checkpoints Focus on p53 Checkpoint

  27. The p53 Cell Cycle Checkpoint

  28. Apoptosis in Digit Formation Pg. 625

  29. Cellular Changes During Apoptosis

  30. Apoptotic Cell Normal Cell

  31. Apoptosis Pathways

  32. The “Death” Receptor

  33. Caspase Activation Pg. 627

  34. Caspase Cascade Pg. 627

  35. Release of Cytochrome C from Mitochondria Pg. 628

  36. Apoptosis Pathways Type I Type II Intrinsic Pathway

  37. Pathways Disrupted in Cancer Cells

  38. Egg Cell and Sperm Cells Pg. 661

  39. Overview of Mammalian Development

  40. Asymmetric Cell Divisions of Meiosis (Metaphase II) (Mitosis)

  41. 50 µm “Cleavage” Divisions 8 cell Embryo (morula)

  42. 50 µm Blastocycst Uterus Inner Cell Mass (ICM) Blastocyst Blastocoel Trophoblast

  43. Early Embryonic Development (~ 7 days)

  44. Drosophila melanogaster (a.k.a. Fruit Fly)

  45. The eyeless (ey) Gene Controls Eye Development

  46. Ectopic Expression of ey Gene Pg. 288

  47. Expression of ey Gene in Leg Precursor Cells

  48. Group of cells that give rise to adult wing Ectopic Expression of Mouse ey Gene Pg. 288

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