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Optic Nerve Development Simulation: Design & Implementation

This project focuses on modeling central nervous system generation and repair through micro-environmental interactions. Data structures include tables for axons, oligodendrocytes, myelin, and astrocytes with detailed aspects and processes. Design of tables in SQL format and future tasks are outlined.

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Optic Nerve Development Simulation: Design & Implementation

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  1. Design and Development of a Discrete Simulation for Optic Nerve Development By: Brent Hefty Greg Tevis Project Advisor: Samuel F. Hunter, M.D., Ph.D.

  2. Overall Purpose • To design and implement a simulation for central nervous system generation and repair as a function of micro-environmental interactions.

  3. Data Structure Development • Main Tables • Axon Table • Oligodendrocyte Table • Myelin Table • Astrocyte Table • Astrocyte Process Table

  4. Axon Table • Important aspects • position • time

  5. Oligodendrocyte Table • Important aspects: • sheath number • time

  6. Oligodendrocyte Representation

  7. Myelin Table • Important aspects • time • references back to other table

  8. Myelination Process Representation • Myelination Process Components • Myelinating Oligodendrocyte • Process attached to axon • Maximum of 10 - 20 turns at .07 um per turn. • Hypertophication after mylination

  9. Astrocyte Table • Important aspects • time • position (due to size)

  10. Astrocyte Process Table • Important aspects • branching • branching ID

  11. Astrocyte Representation

  12. Design of Table in SQL • Use SQL Server Enterprise Manager • Select New Table option • Fill in fields according to model: • Column Name • Datatype • Length • Precision • Scale • Allow Nulls • Default Value • Identity • Identity Seed • Identity Increment

  13. Change of Table Values • Initial Table • Record Table • Updated Table

  14. SQL Can publish to web Cannot import HTML tables Cannot hyperlink datatype Automatic backups Transaction log backup Automatic recovery Max. database size: 1,048,516 terabytes Very Large Database (VLD) support No built-in reporting Access Can publish to web Can import HTML tables Can hyperlink datatype No auotmatic backups No transaction log backup No automatic recovery Max. database size: 1.2 GB No Very Large Database (VLD) support Built-in reporting SQL vs. Access

  15. Past Work: SQL is installed Tables are constructed Initial growth parameters and algorithms Future Work: Fill table field values Begin work on algorithm implementation Project Status

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