EGFR Protein Domains

Sep 10, 2014

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EGFR Protein Domains. 768. 858. 774. Amino acids impacted by mutations:. 779. 815. 747-750. 819. Exons:. Synonymous SNP sites:. 787. 903.

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EGFR Protein Domains

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EGFR Protein Domains 768 858 774 Amino acids impacted by mutations: 779 815 747-750 819 Exons: Synonymous SNP sites: 787 903

Bioinformatics for biomedicine Protein domains and 3D structure

Bioinformatics for biomedicine Protein domains and 3D structure Lecture 4, 2006-10-10 Per Kraulis http://biomedicum.ut.ee/~kraulis What is bioinformatics? Basic databases and tools Sequence searches: BLAST, FASTA Multiple alignments, phylogenetic trees

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Characterizing Alternative Splicing With Respect To Protein Domains

Characterizing Alternative Splicing With Respect To Protein Domains. BME 220 Project Charlie Vaske. Overview. Background Methods and Data Preliminary Results Preliminary Conclusions. Big Picture. Genome. Transcriptome. Proteome. DNA. RNA. Protein. Splicing in Higher Eukaryotes.

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Domains

Domains. The 3 Domains are Archaea , Eubacteria and Eukaryota ( Eukarya ) Each Domain includes 1 or more Kingdoms Domains are bigger than Kingdoms Archaea = Archaebacteria Eubacteria = Eubacteria Eukaryota = Animals, Plants, Protist , Fungi. Autotrophs.

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EGFR Pathway

EGFR Pathway. EGFR, also termed HER1 Regulates cell division, repair, survival 1 Likely involved in tumor metastasis 1 Contains an intracellular tyrosine kinase (TK) domain 1 Overexpressed in tumors but in low levels on normal cells 1

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Domains

Domains. Broadest , most inclusive taxon Three domains 1. Archaea and 2.Eubacteria are unicellular prokaryotes (no nucleus or membrane-bound organelles) 3. Eukarya are more complex and have a nucleus and membrane-bound organelles.

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Domains

Domains. Monera / bacteria. Archea. Archaea is derived from the Greek word archaios , meaning “ancient” or “primitive,” and indeed some archaea exhibit a group of single-celled organisms cells lack a defined nucleus )

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Identification of Protein Domains

Identification of Protein Domains. Eden Dror Menachem Schechter. Computational Biology Seminar 2004. Overview. Introduction to protein domains. Classification of homologs. Representing a domain. PSSM HMM Internet resources Pfam SMART PROSITE InterPro Research example.

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Protein Motifs: EGF Domains

Protein Motifs: EGF Domains. Alison Skinner RCPath Self Help Course 7 th December 2008. Structure of EGF Domains. 30-40 amino acids stabilised by disulphide connectivity Six conserved cysteine residues forming three disulphide bonds in the conformation a n b n a c b c c n c c

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EGFR mutations

Pooled analysis of clinical outcomes in studies of patients with EGFR mutations treated with either an EGFR TKI or chemotherapy. Luis Paz-Ares 1 , Denis Soulières 2 , Barbara Klughammer 3 , Ivan Melezínek 4 , Joachim Moecks 5 , Tony Mok 6

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EGFR-L858R-T790M

A. 1. 2. 3. 4. EGFR-L858R-T790M. CCSP-rtTA. Tet-O-Cre. Floxed WT. C tnnb1. Excised Ctnnb1 (lung). B. 1. 4. 3. EGFR-L858R-T790M. Actin.

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Protein domains vs. structure domains - an example.

Protein domains vs. structure domains - an example. Genome of the week. Nanoarchaeum equitans - archaea Hyperthermophile Diverged early in evolution from other archaea New kingdom of archaea? Obligate symbiont with Ignicoccus Smallest completely sequenced genome <500kB

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Protein Motifs-RNA Binding Domains

Protein Motifs-RNA Binding Domains. 21/02/2008. RNA Binding proteins. Typically cytoplasmic or nuclear At least 9 families RNA binding proteins identified but few have had their structures experimentally determined (those that have are mainly ribosomal proteins)

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Epidermal Growth Factor Receptor (EGFR) the transmembrane + juxtamembrane domains

151. 151. 312. 312. 481. 481. 621. 621. 687. 687. 955. 955. 1186. 1186. L1. L1. CR1. CR1. L2. L2. CR2. CR2. Kinase. Kinase. CT. CT. JM. JM. 644. 644. Extracellular portion. Extracellular portion. Intracellular portion. Intracellular portion.

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DOMAINS

In the interim the business manager and the financial controller will report to the CEO pending the COO role being filled if the CEO appoints a COO. Legal provider. COO. Comms expert. Accountant & Payroll. HR expert. Business Mgr. Financial controller. IT Facilities H&S Exec.

167 views • 1 slides

Bioinformatics for biomedicine Protein domains and 3D structure

Bioinformatics for biomedicine Protein domains and 3D structure. Lecture 4, 2006-10-10 Per Kraulis http://biomedicum.ut.ee/~kraulis. What is bioinformatics? Basic databases and tools Sequence searches: BLAST, FASTA Multiple alignments, phylogenetic trees

465 views • 25 slides

Systematic Identification of Protein Domains for Structure Determination

Systematic Identification of Protein Domains for Structure Determination. Ming Luo, Ph.D. University of Alabama at Birmingham March 29, 2004 NIH. Current Progress on C. elegans Proteins. * Unique ORFs, each expressed and purified multiple times. Markley. Domain Identification. Methods

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Domains

Domains. Load. feeding. Motor. Predictive On-Line. - CSA Current Signature Analysis (Analysis of the current firm) ¿Who does the analysis? AC, DC, Motors y Generators Direct: 600 volts - 3000 Amps Indirect: Unlimited. Electrical predictive. Dielectric Discharge

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EGFR Mutation

S-Table 1. Tang et al., BJC. NSCLC Cell Lines. SW900. H2122. H1975. H1437. H1838. H441. H520. H596. H661. H226. A549. EGFR Mutation. KRAS Mutation. Erlotinib Sensitivity. Histology. Gender.

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Protein families, domains and motifs for functional prediction

Protein families, domains and motifs for functional prediction. June 27, 2019. Outline. Usefulness of protein domain analysis Types of protein domain databases SMART, HMMER and Interpro protein domain database Uniprot protein annotation Predicting post-translational modifications.

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Bioinformatics for biomedicine Protein domains and 3D structure

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Protein evolution The role of domains

Protein evolution The role of domains. Alice Skoumalová. Definition of a domain an independent structural, functional and evolutionary unit Structural unit Self-stabilizing locally folded region of tertiary structure Combination of motifs α -helix a nd β -sheet

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Protein domains, function and associated prediction

C. E. N. T. E. R. F. O. R. I. N. T. E. G. R. A. T. I. V. E. B. I. O. I. N. F. O. R. M. A. T. I. C. S. V. U. Lecture 14:. Protein domains, function and associated prediction. Introduction to Bioinformatics. Functional Genomics – Systems Biology. Genome.

816 views • 79 slides

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