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ENHANCED MS WITH THE TURN OF KEY

ENHANCED MS WITH THE TURN OF KEY. Introducing ionKey/MS. What does ionKey/MS™ deliver? 2-40x sensitivity vs. your current MS UPLC ® performance and reliability Standardization and consistency Flexibility . In Search of a Step Change in Sensitivity? .

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ENHANCED MS WITH THE TURN OF KEY

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  1. ENHANCED MS WITH THE TURN OF KEY

  2. Introducing ionKey/MS • What does ionKey/MS™ deliver? • 2-40x sensitivity vs. your current MS • UPLC® performance and reliability • Standardization and consistency • Flexibility

  3. In Search of a Step Change in Sensitivity?

  4. Xevo® TQ-SA Step Change in Sensitivity Maximizing signal Maximizing robustness

  5. Xevo TQ-SA Step Change in Sensitivity Xevo TQ-S Enhanced sensitivity >25X increase in peak area>5X increase in signal:noise Relative ion abundance Xevo TQ Reserpine (50fg) UPLC/MRM

  6. Where Next to Look for Sensitivity?

  7. Where to Next? 75µm ID 150µm ID 300µm ID + Fast and Sensitive Useable routinely Very Sensitive Flow rates too low for routine use Very Fast Marginal sensitivity increase 0

  8. PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS

  9. PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS

  10. More Sensitivity Standard 2.1mm column ionKey/MS 20X Increase

  11. More Sensitivity ionKey/MS 2Fold suppression in signal due to Matrix Effects 2.1mm 24Fold suppression in signal due to Matrix Effects ionKey/MS Standard Flow LC-MS

  12. PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS

  13. UPLC Performance You Know

  14. PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS

  15. Capillary scale UPLC can be challenging Reproducibility Robustness User Expertise Requirement Applicability to Routine Sensitivity

  16. ionKey/MS is Plug and Play • ENHANCED MS WITH THE TURN OF KEY

  17. PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS

  18. Robust, Reliable Reproducible Reproducibility of the same compound over: Retention Time Reproducibility 15 QCs over 500 crashed plasma injections 5 Users 5 Systems 18 iKeys 1.64% RSD

  19. Validated Assay Teriparadite (Forteo®) Avg MWT 4117.7

  20. PLUG AND PLAY MORE SENSITIVITY UPLC PERFORMANCE YOU KNOW ROBUST REPRODUCIBLE RELIABLE THE FUTURE OF MS

  21. The Future of MS Already over 25 publications and presentations in leading scientific journals and conferences such as: Journal of Chromatography, Bioanalysis Journal, Journal of Proteomics, ASMS, HPLC, EBF CPSA, and more.

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