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Mechanism of Insulin Secretion by  -cells

Mechanism of Insulin Secretion by  -cells. ROLE OF THE K ATP CHANNEL. NO K ATP CHANNEL ACTIVITY, MEMBRANE DEPOLARIZATION AND HIGHER [Ca 2+ ]i IN PANCREATIC Kir6.2 -/- β-CELLS. GLUCOSE AND TOLBUTAMIDE NO LONGER STIMUALTE INCREASES IN [Ca 2+ ]i IN Kir6.2 -/- β-CELLS.

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Mechanism of Insulin Secretion by  -cells

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  1. Mechanism of Insulin Secretion by -cells ROLE OF THE KATP CHANNEL

  2. NO KATP CHANNEL ACTIVITY, MEMBRANE DEPOLARIZATION AND HIGHER [Ca2+]i IN PANCREATIC Kir6.2-/- β-CELLS

  3. GLUCOSE AND TOLBUTAMIDE NO LONGER STIMUALTE INCREASES IN [Ca2+]i IN Kir6.2-/- β-CELLS

  4. GLUCOSE NO LONGER STIMULATE INSULIN SECRETION IN Kir6.2-/- β-CELLS

  5. NEAR NORMAL GLUCOSE TOLERANCE AND INCREASED INSULIN SENSITIVITY IN Kir6.2-/- MICE

  6. INFILTRATION OF α-CELLS IN THE MIDDLE OF THE Kir6.2-/- PANCREATIC ISLETS

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