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Molecular Genetics Are we controlled by our DNA ?

Molecular Genetics Are we controlled by our DNA ?. Refer to pg 119-150 in Holtzclaw , Ch 16-21 in Campbell. Last year. What do you remember of DNA Replication and Protein Synthesis? DNA > mRNA > protein genetic info message action molecule.

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Molecular Genetics Are we controlled by our DNA ?

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  1. Molecular GeneticsAre we controlled by our DNA? Refer to pg 119-150 in Holtzclaw, Ch 16-21 in Campbell

  2. Last year... • What do you remember of DNA Replication and Protein Synthesis? DNA > mRNA > protein genetic info message action molecule mRNA processing DNA Replication Transcription Translation

  3. So What? • Making the big connections... • How many cells do you have? • Compare the DNA in each of your cells • Compare the protein products in each of your cells... • How does your body KNOW when to make some proteins and not others? • THIS is gene expression

  4. So What? • Model Organism: The Fruit Fly

  5. So What? • More flies! • - Using Gene expression to study eye development

  6. What do you think? Are you controlled by your DNA? What are the implications of studying Gene expression? • 1) Free Write (3 min) • 2) Learning Walk (5 min) • 3) No Hands Discussion (5 min)

  7. Review last year… • Learning Intentions!

  8. Gene Expression You must know: • The functions of the three parts of an operon • The role of repressor genes in operons • The impact of DNA methylation and histone acetylation on gene expression • The role of gene regulation in embryonic development and cancer.

  9. Gene Expression Rather important, don’t you think?: • The functions of the three parts of an operon • The role of repressor genes in operons • The impact of DNA methylation and histone acetylation on gene expression • The role of gene regulation in embryonic development and cancer.

  10. The Operon – p. 131 in Holtz. • What is it? • Unit of genetic function • Found in bacteria/phages/some eukaryotes • Consists of: • Promotor – site of RNA polymerase binding • Operator – controls access of RNA polymerase within the promotor • Genes of the Operon –regulated together by the operon

  11. Regulatory Genes • What do they do? • Produce repressor proteins that bind to the operator of an operon to block RNA polymerase from transcribing • Repressible Operon • Usually “on,” can be inhibited... • Inducible Operon • Usually “off,” can be induced... Let’s Make the Connections!

  12. The Try Operon – Repressible

  13. The Lac Operon – Inducible

  14. Let’s make sure we get this… • Handout… • Act Out!

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