1 / 8

UPDATE ON RESEARCH BETA CELLS

UPDATE ON RESEARCH BETA CELLS.  IN VITRO AND ANIMAL MODELS Erol CERASI  HUMAN STUDIES Stephano DEL PRATO. Brea, Cimez, Nice. autoantibodies DNA. DNA pancreatic imaging hormones biological scan. TYPE 2 DIABETES. DIABETES. TYPE 1 DIABETES. O T H E R S.

neal
Télécharger la présentation

UPDATE ON RESEARCH BETA CELLS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. UPDATE ON RESEARCHBETA CELLS  IN VITRO AND ANIMAL MODELS Erol CERASI  HUMAN STUDIES Stephano DEL PRATO Brea, Cimez, Nice

  2. autoantibodies DNA DNA pancreatic imaging hormones biological scan TYPE 2 DIABETES DIABETES TYPE 1 DIABETES O T H E R S • monogenic forms of diabetes • complex genetic disorders • pancreatic diseases • iatrogenic diabetes • diabetes associated with endocrinopathies

  3. islet of Langerhans insulin ß-CELL

  4. TYPE 1 DIABETES: A MULTIGENIC DISEASE MHC class II chr 6 CTLA-4 ICOS1 2q33 5 ’ VNTR insulin gene 11p15 10q 6q27 6q21 10p11 11q13 6q24 IDDM 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 AIRE APECED FOXP3 IPEX

  5. MODY Glucokinase HNF1-a HNF1-b HNF4-a IPF-1 TYPE 2 DIABETES: A MULTIGENIC DISEASE Calpain10 2p37 12q15 NIDDM 1 2 3 4 5 6 7 8 9 10 - - - - - - - - - - - - - - - - - MUTATIONS Insulin receptor Insulin Trypsinogen Frataxine CFTR Mitochondrial DNA HFE

  6. Rab27a-granulophiline Syntaxine 1a, Munc 18.1 ß-CELL Jing X et al., J Clin Invest, 2005 :146 Kasai K et al. J Clin Invest, 2005 : 388

  7. INSULIN SECRETORY DEFECTS IN TYPE 2 • Reduced early insulin secretory response to oral glucose • Reduced first phase insulin response to i.v. glucose • Reduced ability of b cells to compensate for insulin-resistance • Decreased glucose sensing ability of the b cell • Shift in the dose response curve relating glucose and insulin secretion • Alterations in oscillations of insulin secretion Hyperglycemic glucose clamp Response to oscillatory glucose infusion

  8. 5 ’ VNTR insulin gene 11p15 IDDM12 3 …. **association studies  linkage studies UKPDS Lancet, 1998 KEY ISSUES • role of b cells in type 1 diabetes immune failure ? • a decreased b cell mass in type 2 diabetes ? • a unique functional defect of b cells in type 2 diabetes ? • biological diagnostic parameters in type 2 diabetes ? • clinical tests to evaluate b cell function in clinic ?

More Related