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A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic Predications

A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic Predications. Delroy Cameron, Olivier Bodenreider , Hima Yalamanchili , Tu Danh , Sreeram Vallabhaneni , Krishnaprasad Thirunarayan , Amit P. Sheth and Thomas C. Rindflesch. Experiment 1:Run Final.

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A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic Predications

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  1. A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic Predications Delroy Cameron, Olivier Bodenreider, HimaYalamanchili, TuDanh, SreeramVallabhaneni, KrishnaprasadThirunarayan, Amit P. Sheth and Thomas C. Rindflesch

  2. Experiment 1:Run Final

  3. Primary Association 1: Platelet Aggregation (path#1) • Dietary Fish Oil->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Epoprostenol = Prostacyclin (PGI2) Dietary Fish Oil = EPA/FOD/FO Epoprostenol EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils DISRUPTS STIMULATES TREATS DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome DISRUPTS CAUSES

  4. Supplementary Association: Platelet Aggregation (path 1a) • Dietary Fish Oil->PRODUCES->Prostaglandin (PGI3)-> INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Prostaglandin Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils ISA DISRUPTS ISA Epoprostenol ISA DISRUPTS CONVERTS_TO Prostaglandin I3 STIMULATES TREATS DISRUPTS CONVERTS_TO DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome CAUSES DISRUPTS Epoprostenol = Prostacyclin (PGI2)

  5. Secondary Association: Platelet Aggregation (path 1.1) • Prostaglandin (PGE1)->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Alprostadil DISRUPTS INTERACTS_WITH DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome DISRUPTS CAUSES Alprostadil = Prostaglandin (PGE1)

  6. Secondary Association: Platelet Aggregation (path 1.2) • Prostacyclin (PGI2)->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol DISRUPTS/ INHIBITS_MAN/PREVENTS_MAN STIMULATES TREATS DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome DISRUPTS CAUSES Epoprostenol = Prostacyclin (PGI2)

  7. Secondary Association: Platelet Aggregation (path 1.3) • Nifedipine->ISA-CCB->INHIBITS->platelet activation->ASSOCIATED_WITH->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol STIMULATES TREATS DISRUPTS Platelet Aggregation Raynaud Syndrome DFO/EPA/FOD/FO DISRUPTS CAUSES DISRUPTS TREATS Nifedipine ISA Calcium Channel Blocker

  8. Primary Association 2: Blood Viscosity (path#2) • Dietary Fish Oil->INHIBITS->Blood Viscosity->CAUSES ->Raynaud Syndrome Epoprostenol = Prostacyclin (PGI2) Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol STIMULATES TREATS DISRUPTS DFO/EPA/FOD/FO Blood Viscosity Raynaud Syndrome DISRUPTS CAUSES DISRUPTS TREATS Ketanserin

  9. Supplementary Association: Blood Viscosity (path 2a) • Dietary Fish Oil->INHIBITS->triglyceride->ISA->Blood Lipid->AFFECTS->Blood Viscosity->CAUSES ->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Essential Fatty Acid Lipid INHIBITS ISA ISA Fatty Acid Triglyceride ISA ISA AFFECTS DFO/EPA/FOD/FO Blood Viscosity Raynaud Syndrome DISRUPTS CAUSES

  10. Secondary Association: Blood Viscosity (path 2.1) • Prostacyclin (PGI2)->AUGMENTS->Erythrocyte Deformability->INHIBITS->Blood Viscosity-> CAUSES ->Raynaud Syndrome (in vitro) Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol TREATS STIMULATES DISRUPTS AFFECTS/DISRUPTS DFO/EPA/FOD/FO Raynaud Syndrome Blood Viscosity CAUSES DISRUPTS TREATS Ketanserin Epoprostenol = Prostacyclin (PGI2)

  11. Secondary Association: Blood Viscosity (path 2.2) • Ketanserin->INHIBITS->serotonin->AUGMENTS->Erythrocyte Deformability->INHIBITS->Blood Viscosity • -> CAUSES ->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils AFFECTS/DISRUPTS DFO/EPA/FOD/FO Raynaud Syndrome Blood Viscosity CAUSES DISRUPTS TREATS Ketanserin

  12. Primary Association: Vascular Reactivity (path#3) Dietary Fish Oil->INHIBITS->Vascular Reactivity->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol INHIBITS_MAN AFFECTS_MAN TREATS Vascular Reactivity DFO/EPA/FOD/FO Raynaud Syndrome AFFECTS_MAN CAUSES

  13. Supplementary Association: Vascular Reactivity (path 3a, 3b) • Dietary Fish Oil-> PRODUCES->Prostaglandin (PGI3)->CAUSES->vasodilation->INHIBITS->Raynaud Phenomenon • Dietary Fish Oil-> PRODUCES->Prostaglandin (PGI3)->INHIBITS ->vasoconstriction->CAUSES->Raynaud Phenomenon Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol ISA INHIBITS_MAN TREATS Prostaglandin I3 AFFECTS_MAN TREATS INHIBITS_MAN CONVERTS_TO DFO/EPA/FOD/FO Vascular Reactivity Raynaud Syndrome CAUSES INHIBITS_MAN

  14. Secondary Association: Vascular Reactivity (path 3.2) Prostacyclin (PGI2)->CAUSES->vasodilation->INHIBITS ->Raynaud Phenomenon Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol INHIBITS_MAN AFFECTS_MAN TREATS Vascular Reactivity DFO/EPA/FOD/FO Raynaud Syndrome AFFECTS_MAN CAUSES Epoprostenol = Prostacyclin (PGI2)

  15. Secondary Association: Vascular Reactivity (path 3.3) • Nifedipine->ISA-CCB->INHIBITS->platelet activation->ASSOCIATED_WITH->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Vascular Reactivity Raynaud Syndrome DFO/EPA/FOD/FO AFFECTS_MAN CAUSES INHIBITS_MAN TREATS Nifedipine ISA Calcium Channel Blocker

  16. Experiment 2:Run Final

  17. Primary Association: Platelet Aggregation (path#1) • Dietary Fish Oil->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol PRODUCES STIMULATES TREATS Endothelial Cells LOCATION_OF DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome

  18. Supplementary Association: Platelet Aggregation (path 1a) • Dietary Fish Oil->PRODUCES->Prostaglandin (PGI3)-> INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Prostaglandin I3 ISA CONVERTS_TO Epoprostenol TREATS STIMULATES Platelet Aggregation DFO/EPA/FOD/FO Raynaud Syndrome

  19. Primary Association: Blood Viscosity (path#2) • Dietary Fish Oil->INHIBITS->Blood Viscosity->CAUSES ->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol TREATS DISRUPTS STIMULATES Raynaud Syndrome Blood Viscosity DFO/EPA/FOD/FO DISRUPTS CAUSES TREATS AFFECTS Ketanserin

  20. Epoprostenol Epoprostenol p1 p1 TREATS TREATS STIMULATES STIMULATES RS RS DFO DFO ISA CONVERTS_TO CONVERTS_TO CAUSES CAUSES Prostaglandin (PGI3) Prostaglandin (PGI3) INHIBITS INHIBITS p2 p2 Platelet aggregation Platelet aggregation

  21. Background Knowledge Predications Graph Corpus • Semantic Association • Generator Semantic Predication Extractor (SemRep) Subgraph

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