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Swanson's Hypothesis Recovery & Decomposition: Semantic Predications Experiment

This experiment examines associations between dietary fish oil, platelet aggregation, blood viscosity, and Raynaud Syndrome based on semantic predications. Various pathways and secondary associations are analyzed to elucidate the complex relationships involved.

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Swanson's Hypothesis Recovery & Decomposition: Semantic Predications Experiment

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  1. A Graph-Based Recovery and Decomposition of Swanson’s Hypothesis using Semantic Predications Delroy Cameron, Olivier Bodenreider, HimaYalamanchili, TuDanh, SreeramVallabhaneni, KrishnaprasadThirunarayan, Amit P. Sheth and Thomas C. Rindflesch

  2. Experiment 1:Run Final

  3. Primary Association 1: Platelet Aggregation (path#1) • Dietary Fish Oil->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Epoprostenol = Prostacyclin (PGI2) Dietary Fish Oil = EPA/FOD/FO Epoprostenol EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils DISRUPTS STIMULATES TREATS DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome DISRUPTS CAUSES

  4. Supplementary Association: Platelet Aggregation (path 1a) • Dietary Fish Oil->PRODUCES->Prostaglandin (PGI3)-> INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Prostaglandin Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils ISA DISRUPTS ISA Epoprostenol ISA DISRUPTS CONVERTS_TO Prostaglandin I3 STIMULATES TREATS DISRUPTS CONVERTS_TO DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome CAUSES DISRUPTS Epoprostenol = Prostacyclin (PGI2)

  5. Secondary Association: Platelet Aggregation (path 1.1) • Prostaglandin (PGE1)->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Alprostadil DISRUPTS INTERACTS_WITH DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome DISRUPTS CAUSES Alprostadil = Prostaglandin (PGE1)

  6. Secondary Association: Platelet Aggregation (path 1.2) • Prostacyclin (PGI2)->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol DISRUPTS/ INHIBITS_MAN/PREVENTS_MAN STIMULATES TREATS DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome DISRUPTS CAUSES Epoprostenol = Prostacyclin (PGI2)

  7. Secondary Association: Platelet Aggregation (path 1.3) • Nifedipine->ISA-CCB->INHIBITS->platelet activation->ASSOCIATED_WITH->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol STIMULATES TREATS DISRUPTS Platelet Aggregation Raynaud Syndrome DFO/EPA/FOD/FO DISRUPTS CAUSES DISRUPTS TREATS Nifedipine ISA Calcium Channel Blocker

  8. Primary Association 2: Blood Viscosity (path#2) • Dietary Fish Oil->INHIBITS->Blood Viscosity->CAUSES ->Raynaud Syndrome Epoprostenol = Prostacyclin (PGI2) Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol STIMULATES TREATS DISRUPTS DFO/EPA/FOD/FO Blood Viscosity Raynaud Syndrome DISRUPTS CAUSES DISRUPTS TREATS Ketanserin

  9. Supplementary Association: Blood Viscosity (path 2a) • Dietary Fish Oil->INHIBITS->triglyceride->ISA->Blood Lipid->AFFECTS->Blood Viscosity->CAUSES ->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Essential Fatty Acid Lipid INHIBITS ISA ISA Fatty Acid Triglyceride ISA ISA AFFECTS DFO/EPA/FOD/FO Blood Viscosity Raynaud Syndrome DISRUPTS CAUSES

  10. Secondary Association: Blood Viscosity (path 2.1) • Prostacyclin (PGI2)->AUGMENTS->Erythrocyte Deformability->INHIBITS->Blood Viscosity-> CAUSES ->Raynaud Syndrome (in vitro) Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol TREATS STIMULATES DISRUPTS AFFECTS/DISRUPTS DFO/EPA/FOD/FO Raynaud Syndrome Blood Viscosity CAUSES DISRUPTS TREATS Ketanserin Epoprostenol = Prostacyclin (PGI2)

  11. Secondary Association: Blood Viscosity (path 2.2) • Ketanserin->INHIBITS->serotonin->AUGMENTS->Erythrocyte Deformability->INHIBITS->Blood Viscosity • -> CAUSES ->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils AFFECTS/DISRUPTS DFO/EPA/FOD/FO Raynaud Syndrome Blood Viscosity CAUSES DISRUPTS TREATS Ketanserin

  12. Primary Association: Vascular Reactivity (path#3) Dietary Fish Oil->INHIBITS->Vascular Reactivity->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol INHIBITS_MAN AFFECTS_MAN TREATS Vascular Reactivity DFO/EPA/FOD/FO Raynaud Syndrome AFFECTS_MAN CAUSES

  13. Supplementary Association: Vascular Reactivity (path 3a, 3b) • Dietary Fish Oil-> PRODUCES->Prostaglandin (PGI3)->CAUSES->vasodilation->INHIBITS->Raynaud Phenomenon • Dietary Fish Oil-> PRODUCES->Prostaglandin (PGI3)->INHIBITS ->vasoconstriction->CAUSES->Raynaud Phenomenon Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol ISA INHIBITS_MAN TREATS Prostaglandin I3 AFFECTS_MAN TREATS INHIBITS_MAN CONVERTS_TO DFO/EPA/FOD/FO Vascular Reactivity Raynaud Syndrome CAUSES INHIBITS_MAN

  14. Secondary Association: Vascular Reactivity (path 3.2) Prostacyclin (PGI2)->CAUSES->vasodilation->INHIBITS ->Raynaud Phenomenon Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol INHIBITS_MAN AFFECTS_MAN TREATS Vascular Reactivity DFO/EPA/FOD/FO Raynaud Syndrome AFFECTS_MAN CAUSES Epoprostenol = Prostacyclin (PGI2)

  15. Secondary Association: Vascular Reactivity (path 3.3) • Nifedipine->ISA-CCB->INHIBITS->platelet activation->ASSOCIATED_WITH->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Vascular Reactivity Raynaud Syndrome DFO/EPA/FOD/FO AFFECTS_MAN CAUSES INHIBITS_MAN TREATS Nifedipine ISA Calcium Channel Blocker

  16. Experiment 2:Run Final

  17. Primary Association: Platelet Aggregation (path#1) • Dietary Fish Oil->INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol PRODUCES STIMULATES TREATS Endothelial Cells LOCATION_OF DFO/EPA/FOD/FO Platelet Aggregation Raynaud Syndrome

  18. Supplementary Association: Platelet Aggregation (path 1a) • Dietary Fish Oil->PRODUCES->Prostaglandin (PGI3)-> INHIBITS->platelet aggregation->CAUSES->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Prostaglandin I3 ISA CONVERTS_TO Epoprostenol TREATS STIMULATES Platelet Aggregation DFO/EPA/FOD/FO Raynaud Syndrome

  19. Primary Association: Blood Viscosity (path#2) • Dietary Fish Oil->INHIBITS->Blood Viscosity->CAUSES ->Raynaud Syndrome Dietary Fish Oil = EPA/FOD/FO EPA – Eicosapentaenoic Acid FOD – Fish Oil – dietary FO – Fish Oils Epoprostenol TREATS DISRUPTS STIMULATES Raynaud Syndrome Blood Viscosity DFO/EPA/FOD/FO DISRUPTS CAUSES TREATS AFFECTS Ketanserin

  20. Epoprostenol Epoprostenol p1 p1 TREATS TREATS STIMULATES STIMULATES RS RS DFO DFO ISA CONVERTS_TO CONVERTS_TO CAUSES CAUSES Prostaglandin (PGI3) Prostaglandin (PGI3) INHIBITS INHIBITS p2 p2 Platelet aggregation Platelet aggregation

  21. Background Knowledge Predications Graph Corpus • Semantic Association • Generator Semantic Predication Extractor (SemRep) Subgraph

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