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Advancing Brain Barriers Research: A Cross-disciplinary Approach

The Brain Barriers Research Center (BBRC) at the University of Minnesota College of Pharmacy and Medical School conducts innovative research to enhance drug delivery to the central nervous system (CNS). The center focuses on areas such as targeted drug delivery, drug transport proteins, and pharmacokinetics to improve therapies for brain disorders. With a mission to foster interdisciplinary research, BBRC explores the regulation of BBB transporters in Alzheimer's disease, BBB function in CNS disorders, and more. The center collaborates with institutes like the Institute for Translational Neuroscience and the Center for Magnetic Resonance Research. Current projects include neurosurgery, gliomas, and blood-brain barrier modification, aiming to push the boundaries of brain barrier research. For more information, visit the BBRC website at www.pharmacy.umn.edu/bbrc

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Advancing Brain Barriers Research: A Cross-disciplinary Approach

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  1. Brain Barrier Research Center: A Multidisciplinary Approach to Advancing Brain Barriers Research William Elmquist, John Ohlfest, Lester Drewes, et al. University of Minnesota College of Pharmacy and Medical School • Targeted drug delivery to the CNS • Drug transport proteins • Pharmacokinetics Decisions limited by available data at specific sites input Mission output bolus IC, CED exchange neuronal and glial cell mem- branes The mission of the Brain Barriers Research Center (BBRC) is to improve therapy delivery and treatments of brain disordersby fostering interdisciplinary brain barrier research. extra- cellular fluid brain capillaries intracellular fluid IV plasma choroid plexus arachnoid membrane ependyma pia mater ICV, IT cerebrospinal fluid Compartmental model for solute exchange in the brain • MCT1 and GLUT1 transporter regulation • BBB molecular biology • Brain vasculogenesis The Brain Barriers Research Center (BBRC) is a distinctive, cutting edge University of Minnesota research group involving members in the College Goals • Basic Science to Clinical Practice • Experimental Models • Pharmacokinetics/ pharmacodynamics • High throughput screening/assay develop • In situ brain profusion techniques • In vitro to in vivo • MRI/MRS to microdialysis • Blood-brain transport quantification Expertise • Role of BBB transporters in Alzheimer's disease • BBB function in CNS disorders of Pharmacy and the Medical School in the Academic Health Center (Duluth and Twin Cities). Twenty-two faculty are involved in research ranging from genetic factors in hibernation to synthesis of neuroactive pharmaceutics. • Regulation of drug efflux transporters at the BBB • Improving therapies for CNS diseases University Collaborative Resources • Institute for Translational Neuroscience (www.itn.umn.edu) • Center for Translational Medicine (www.ahc.umn.edu/ctm) • Center for Magnetic Resonance Research (www.cmrr.umn.edu) • Institute for Therapeutics Discovery and Development • Epilepsy • Stroke • Brain tumor (glioblastoma, GBM) • Alzheimers Disease • CNS virus • Parkinson’s Disease • Glucose transporter deficiency syndrome Current Projects • Neurosurgery • Gliomas • Blood brain barrier modification The University of Minnesota is an equal opportunity educator and employer. BBRC Web Site: www.pharmacy.umn.edu/bbrc

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