Physiology

DESCRIPTION

Bone remodeling is a dynamic process involving osteoblasts, which build bone, and osteoclasts, which resorb it. Key proteins regulate this balance, with RANK Ligand stimulating osteoclast activity and Osteoprotegerin inhibiting RANK Ligand to maintain bone homeostasis. Understanding these cellular processes and interactions is crucial for addressing bone health issues such as osteoporosis. This overview highlights the significance of osteoblasts and osteoclasts in bone physiology and the regulatory mechanisms that control remodeling processes in the body.

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Feb 19, 2026

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Physiology

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Presentation Transcript

Cells of bone remodeling: • Osteoblasts build bone • Osteoclasts resorb bone Osteoblasts Osteoclasts • Proteins that regulate bone remodeling: • RANK Ligand stimulates osteoclasts1 • Osteoprotegerininhibits RANK Ligand2 RANK Ligand RANK Receptor Osteoprotegerin Physiology Osteoclast