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Psychology 3600 Action Potential Saltatory Conduction Ion Channels Membrane Currents

Psychology 3600 Action Potential Saltatory Conduction Ion Channels Membrane Currents. Myelinated Axon. Saltatory Conduction. AP Propagation/ Saltatory Conduction. http://www.blackwellscience.com/matthews/actionp.html. AP Properties. 1. Threshold 2. All-or-none 3. Frequency coding

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Psychology 3600 Action Potential Saltatory Conduction Ion Channels Membrane Currents

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  1. Psychology 3600 Action Potential Saltatory Conduction Ion Channels Membrane Currents

  2. Myelinated Axon

  3. Saltatory Conduction

  4. AP Propagation/ Saltatory Conduction http://www.blackwellscience.com/matthews/actionp.html

  5. AP Properties 1. Threshold 2. All-or-none 3. Frequency coding 4. Passive spread

  6. Action Potential Modification

  7. Patterns of Action Potentials

  8. Sustained Stimulation

  9. Equilibrium Potential

  10. Ion Concentration and Permeability

  11. EK Equilibrium membrane potential for potassium is -75 to -100mV.

  12. ENa Equilibrium membrane potential for sodium is +40 to +60mV.

  13. Action Potential Boundaries ENa EK

  14. An action potential is a rapid change from a potassium dominated potential to a sodium dominated potential and back.

  15. Ion Channels

  16. Ion Channels are Holes in the Membrane

  17. Ion Channel Criteria Single channel conductance Ion selectivity Gating Pharmacology

  18. Patch Clamp Recording of Ion Channels

  19. Patch Clamp Variations

  20. Ion Channel Criteria Single channel conductance Ion selectivity Gating Pharmacology

  21. Hydrated Ions The larger the unhydrated ion in size, the more dispersed is its own charge and the less strongly it will attract water. This leads to the incongruous situation of the larger the ion, the less hydrated it is, and the smaller the relative size of the hydrated whole. Thus, K+ > Na+, but hydrated K+ < hydrated Na+.

  22. I/V Curve-V=IxR

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