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An Overview Of The ALSPAC Data Resource RSS Avon Local Group Meeting 26 th May 2009

An Overview Of The ALSPAC Data Resource RSS Avon Local Group Meeting 26 th May 2009. David Herrick david.herrick@bristol.ac.uk http://www.bristol.ac.uk/alspac/. What is ALSPAC?. “Avon Longitudinal Study of Parents and Children”

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An Overview Of The ALSPAC Data Resource RSS Avon Local Group Meeting 26 th May 2009

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  1. An Overview Of TheALSPAC Data ResourceRSS Avon Local Group Meeting26th May 2009 David Herrick david.herrick@bristol.ac.uk http://www.bristol.ac.uk/alspac/

  2. What is ALSPAC? • “Avon Longitudinal Study of Parents and Children” • Cohort study of children and their parents, based in the former county of Avon (excluding Bath) • Designed to determine ways in which the individual’s genotype combines with environmental pressures to influence health and development

  3. Study design • Eligibility criteria: Mothers had to be resident in the study area and have an expected date of delivery between 1st April 1991 and 31st December 1992 • Avon was broadly representative of the UK as a whole and has a relatively stable population • Core sample of 14,541 pregnancies resulting in 14,062 live born children

  4. Data Sources • Self Completion Questionnaires • Hands on Assessments • Biological Samples • DNA • Direct School Contact • Health Records • Linked Datasets • Sub Studies

  5. Self completion questionnaires (1) • Carer (17, 4 during pregnancy) • Mother’s health, home environment, income, education, employment etc. • Partner (15, 2 during pregnancy) • Child-based, completed by main carer (23) • Child’s health, development, behaviour, diet etc. • Child-completed (22) • Teeth, school, home, hobbies, substance use, mental health etc. • Annual puberty questionnaires (9) • Tanner staging, menarchy

  6. Self completion questionnaires (2) • Miscarriages • Adult Learning (Carer & Partner) • Single mail shot; follow up telephone interview • DCSF Year 11 (Carer & Child) • Education - attitudes & aspirations • Friendships (Child) • Single mail shot; aim to identify which other study children child is friends with

  7. Hands on assessments (1) • Children in Focus • 10% sample seen 10 times between 4 & 61 months • 1432 attended at least 1, 1000 at least 8, 539 all 10 • Physical measures: Anthropometry, blood pressure, lung function, skin, hair & eye observations, allergy testing, vision, hearing, dental • Cognitive measures: habituation, memory, speech • Environmental measures: diet, pollution, parenting, day care • Blood samples

  8. Hands on assessments (2) • Focus Sessions • Annual assessments, starting with Focus@7, to which the whole cohort is invited • Physical: Measures, bone density, fitness, vision, hearing, allergies, blood / saliva samples, vascular function, lung function, acne • Cognitive / behavioural: IQ, speech & language, bullying, antisocial activities, friends, substance use, romantic relations, psychosis, depression

  9. Biological samples • Maternal blood & urine • Paternal blood & saliva • Umbilical cord blood & slices • Placentas • Children’s teeth, hair and nail clippings • Children’s blood, saliva & urine

  10. DNA • DNA for: • ~10,000 children • ~10,000 mothers • ~1,000 partners • ~6700 mother/child pairs • ~700 trios • Blood for cell lines for: • ~7,000 children • ~5,700 mothers • ~1,400 fathers

  11. ALSPAC at School

  12. Direct School Contact (1) • Contact with ~350 primary schools in the four local LEAs: • Bristol • South Gloucestershire • North Somerset • Bath and North East Somerset • Private & special schools included • Parental contact for out of area cases

  13. Direct School Contact (2) • Questionnaires in Year 3 & Year 6: • School (Head teacher) • Class (Class teacher) • Child (Class teacher) • Maths test in Year 4 • Maths, Spelling & Science tests in Year 6 • Year 6 maths test repeated in Year 8

  14. Health Records • Delivery notes • Abstracted by midwives • ~ 8300 in full • ~ 2300 shortened version • ~ 2000 further planned • Convulsions (n  400) • Hospital admissions • Selected from questionnaire responses • Special Care Baby Unit (n  1000)

  15. Linked Datasets • ONS Tracing • Electronic antenatal & birth records • National Pupil Database • Address based • Currently investigating PCT data, HES, Home Office, DWP, HESA

  16. Sub Studies (1) • Avon Brothers and Sisters Study • Becoming a Teenager • Before Breakfast Study • Being 3 • British Gas Study • Bunk Bed Study • DATE (diet and physical activity study) • Deuterium • Family Study • Four Seasons (physical activity calibration study)

  17. Sub Studies (2) • Fractures • Identifying Developmental Impairments • K4 (physical activity calibration study) • Lightbox (as an alternative to anthropometery) • Noise Study • Peanut & Other Allergies • Scan and Swim • Teenager at Thirteen • Twins Secret Language

  18. Response Figures Jan 2002

  19. Data Access Model • Contact ALSPAC via email • Receive CD/Download guide to Data sets • Download Research Proposal Form • Incorporates Data Agreement Form • Submit proposal to ALSPAC Exec • Receive dataset limited to research question/s • Variables are identified by collaborator • Built by ALSPAC statisticians/data staff • Extensions require further submission

  20. Publications

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