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Agenda

Overview of Discovery & Development Informatics at Lilly Rick Bishop, Manager, DDIT Phil Brooks, Information Consultant, DDIT Hans Constandt, Senior Business Consultant, DDIT Andy Ring, Information Consultant, DDIT Susie Stephens, Manager, DDIT. Agenda. Introduction to Lilly

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Agenda

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  1. Overview of Discovery & Development Informatics at LillyRick Bishop, Manager, DDITPhil Brooks, Information Consultant, DDITHans Constandt, Senior Business Consultant, DDITAndy Ring, Information Consultant, DDIT Susie Stephens, Manager, DDIT

  2. Agenda • Introduction to Lilly • Discovery & Development Informatics Plans • External Focus

  3. Introduction to Lilly

  4. Eli Lilly Background • A heritage more than 130 years strong • Headquarters located in Indianapolis, Indiana, USA • Approximately 40,000 employees worldwide • Approximately 8,000 employees engaged in R&D • Clinical research conducted in more than 50 countries • Research and development facilities located in 8 countries • Manufacturing plants located in 13 countries • Products marketed in 143 countries

  5. Breakthrough Products Type 1 & Type 2 Diabetes ** Malignant pleural mesothelioma and lung cancer HumatropeGrowth deficiency ** Type II diabetes (developed and marketed in partnership with Amylin pharmaceuticals) Type 1 & Type 2 Diabetes Cardiac ischemic complications (developed by Centocor, marketed by Lilly) ** Erectile dysfunction ** Treatment of ADHD **Major depression and DPNP (Partnership with Quintiles) ** Treatment of bipolar depression Osteoporosis in women past menopause ** Treatment of severe sepsis ** Osteoporosis for men and women in post menopause who are susceptible to fractures ** Stress urinary incontinence (marketed in Europe with Boehringer Ingelheim) Cancer (pancreatic and non-small-cell lung cancer; bladder and breast cancer in Europe) Schizophrenia, bipolar mania, and bipolar maintenance ** Lilly has launched 9 new products since 2001

  6. Discovery & Development Informatics • Functional Areas • Biology • Chemisty • ADME/Tox • Experimental Medicine • Process R&D • MaryJo Zaborowski, Information Officer • 230 employees globally • Skills • Informatics • Software engineering • Systems integration • Discovery PMO • Discovery COE • External Surveillance

  7. Industry spends more to get less • Source: PhRMA, FDA, Lehman Bros.

  8. Patient-centric Focus

  9. Project Program Product Exploratory Launch Hit To Lead Lead To PgS Target To Hit Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Generate/Test Hypothesis Lead Optimization Pre-Clinical Development Global Launch Phase I Phase 2 Phase 3 Registration Target Hit Lead PgS CS FHD FED PD/RD FS FA FL GL Model & Understand Model & Understand Model & Understand Model & Understand Model & Understand Model & Understand Model & Understand Model & Understand Model & Understand Model & Understand Analyze & Mine Analyze & Mine Analyze & Mine Analyze & Mine Analyze & Mine Analyze & Mine Analyze & Mine Analyze & Mine Analyze & Mine Analyze & Mine Transform Transform Transform Transform Transform Transform Transform Transform Transform Transform Data Data Data Data Data Data Data Data Data Data Silos Need to be Broken Down

  10. Cell/Assay Technologies Integrating Heterogeneous Data

  11. Re-Aligning IT Spend Source: Professor Peter Weill, MIT Sloan School of Management

  12. Discovery & Development Informatics Plans

  13. WS WS WS WS WS WS WS Discovery SOA Components Custom Software Engineering Composite Application Semantic Layer Custom Ontology Data Consumers Workflow/ Business Logic Systems Integration Research Operations Integration Services Mart Data Providers Ops DB Ops DB Ops DB Ops DB Application Application Application Application CRO COTS

  14. A P P S Application 1 Application 2 Application 3 … S O A SOA Layer/Enterprise Service Bus (WebServices, Visualizers, DataAccess Components) Authentication D A T A SQL SPARQL ETL Provenance Source Model 1 Source Model 2 Source Model 3 Source Model 4 Local Assertions Top Level Ontology Other Sources Other Sources Source … Other Tools Spreadsheets Rdbms Discovery Metadata: Architecture

  15. Proposed Architecture Desktop applications Automated Datamarts /Warehouses Lilly Security standards: LillyNet DIT, GMR Client APIs C#, Java, Ruby Browsers & Visualization Semantic pipes Security – http standard Sparql endpoints Top level ontology Middleware - Relational2RDF Manual RDF RDF RDF RDF RDBMS RDBMS RDBMS RDBMS Domain Ontologies & vocabs Domain Ontologies & vocabs Domain Ontologies & vocabs Standardize (*) – (**) Lilly & Public Structured & Unstructured Data sources. RDF RDF CSV XML Docs XLS Web RDBMS RDBMS (*) – Data clean, map to vocabularies, ontologies (**) – URI / Unique resource identifiers

  16. LSG Going Forward • Evolve CAB toward CompositeWCF • Establish ESB • D2R • Establish SOA fabric • Governance - Design time • Monitoring - Run time • Extend semantics within LSG messaging • Incorporate semantic provenance

  17. External Focus

  18. Open Innovation Group Activities • Identify suitable innovation projects from the DDIT portfolio • Work with internal scientist &/or external collaborators to create POCs of the identified projects • Demonstrate value of innovation projects within DDIT • Showcase novel solutions to senior management in LRL • Promote work of group through Web site, newsletter, etc. • Scout for interesting new technologies from universities, standards organizations • Write up brief reviews of interesting technologies for dissemination across DDIT • Organize presentations/demos of appealing technologies to DDIT • Support Lilly’s open source projects • Influence development of 3rd party products to better meet our needs

  19. Benefits of Open Innovation Team • Fast assessment of the value of a technology • Quick delivery of informatics solutions to LRL that meet prioritized scientific needs • Increased awareness of how emerging technologies may change the landscape in 3-5 yrs • Streamlined dissemination of information about new technologies • Use knowledge gained to make best investments going forwards • Establish relationships with key technology players for the future environment • Influence vendors to develop solutions in ways that work for us • Increased success in using tools from academia • More formalized process for developing ‘supported’ technologies • Ability to more easily utilize output from the Open Innovation Center • Raise awareness of DDIT and the importance of IT within LRL

  20. Ongoing Open Innovation Projects • RDF Access to Relational Databases • Eric Prud'hommeaux • End User Semantic Web Authoring • David Karger • Scientist-Driven Semantic Integration of Knowledge in AD • Tim Clark, June Kinoshita • Provenance Collection and Management • Carole Goble, Beth Plale • Linking Open Drug Data • Chris Bizer • Drug Target Networks • Lászó Barabási

  21. Standards Group Participation • W3C • HCLS IG, RDB2RDF XG, Social Networking Workshop, tracking WACG, likely participation in DAWG • CDISC • SDTM, Metadata Repository, SEND • HL7 • The Open Group • EBI’s Industry Consortium

  22. Conclusions • Lilly is a successful mid-sized pharma company • The pharma industry is under considerable pressure to become more effective • Industry shifts requires a greater exploitation of information • Need greater adoption of innovative solutions in cutting edge infrastructure and informatics • LSG, Semantic Web and SOA are all in our architectural plans • Increased focus on external collaborations

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