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Protein Drug Delivery System

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Protein Drug Delivery System

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    1. Protein Drug Delivery System Team Members: Austin Ramme- Team Leader Michael Haggerty- BSAC Andrew Neumann- BWIG Sarajane Stevens- Team Leader-IT Becky Koszalinski- BSAC-IT Christopher Westphal- BWIG-IT

    2. Presentation Outline Problem Statement Background Information Current Devices Research Competition Design Constraints Alternative Designs Future Work

    3. Problem Statement Client: Michael J. MacDonald, MD Diabetes Type I Protein Drug Delivery System Inexpensive Constant Injection Rate Disposable

    4. Background Information Diabetes Type I Immune system Glucose level in the blood Juvenile onset diabetes Injections/Pumps

    5. Background Information Insulin Protein-based drug Onset, peaktime, duration 5 to 10 units/day Unit = 0.01 mL Protein Drugs Skin, ingestion, injection Injection sites

    6. Current Devices: Insulin Pumps Insulin syringe (3) Battery operated pump (2) Computer controlled Infusion set (1) Tube Needle (soft or metal) Very expensive ($5,000 – $7,500)

    7. Research Competition Professor Beebe Hydrogels Stimuli cause expansion in gel Currently toxic Non-linear expansion Wound-dressings Easy to mold

    8. Suggested Materials Metering Valves Controls flow Chromatography NanoMuscles Contract like human muscle Rotational or linear motion Expandable Materials

    9. Design Constraints Inexpensive Disposable Sterile Constant flow 8-24 hour delivery time Scaled up prototype

    10. Design I: Constant Pressure Device Disk shaped reservoir (60mm diameter) Spring applies constant pressure Metering valve controls flow rate

    11. Design I: Advantages & Disadvantages Advantages Compact Flexible Cost efficient Disadvantages Awkward Health risks Advanced technology

    12. Design II: Bulb Gravity Box Ten scale Two chamber Separation membrane Uses gravity Air pressure Adhesive

    13. Advantages Easy filling Inexpensive materials Constant flow rate

    14. Design III: NanoMuscle-Monstrosity (NMM) Batteries in series NanoMuscle Syringe Wire-Needle Flesh colored tube Adhesive undercoating

    15. Design III: Advantages & Disadvantages Advantages Refilling procedure Materials NanoMuscles Disadvantages NanoMuscles Shape/Size

    16. Future Work Flow rate and pressure calculations NanoMuscle research Metering valve search Constructing prototype Test prototype

    17. References [1] Ahern J, Mazur ML. Apr 2001. Site Rotation. Diabetes Forecast. 54,4:66-68. [2] Anonymous. Jan 2004. Insulin Administration. Diabetes Care. 27:S106-S109. [3] The Basics of Insulin. American Diabetes Association. 16 Sept 2004. <http://www.diabetes.org/type-1-diabetes/basics.jsp>. [4] Campbell, R. Keith. “Update on Insulin Injection Devices.” U.S. Pharmacist. 16 Sept 2004. <http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Feat/may00insulin.cfm>. [5] Diabetes Mellitus. Microsoft® Encarta® Online Encyclopedia 2004. 10 Sept 2004. <http://encarta.msn.com>. [6] Flow Rate Calculations. 15 Sept. 2004. <http://www.ecsel.psu.edu/~tac167/flowcalcs.htmL>. [7] Fluid Systems. 15 Sept 2004. <http://claymor.engineer.gvsu.edu/jackh/books/model/chapters/fluids.pdf>. [8] Fomo Products, Inc. 24 Sept 2004. <http://www.fomo.com/msds/a16150.pdf >. [9] Hydrostatic Pressure in a Liquid. 15 Sept 2004. <http://www.ac.wwu.edu/~vawtr/PhysicsNet/Topics/Pressure/Hydrostatic.htmL>. [10] Insulin Routines. American Diabetes Association. 16 Sept 2004 <http://www.diabetes.org/type-1-diabetes/injections.jsp>. [11] Insulin Storage and Syringe Safety Information. American Diabetes Association. 16 Sept 2004. <http://www.diabetes.org/type-1-diabetes/safety.jsp>. [12] Insulin Pump 101. 19 Sept 2004. <http://www.banting.com/tcenter/pump101.htmL>. [13] Insulin Pumps. American Diabetes Association. 10 Sept 2004. http://www.diabetes.org/type-1-diabetes/insulin-pumps.jsp [14] Lumber T. Jul 2004. Tips for Site Rotation. Diabetes Forecast. 57,7:68-70. [15] Kempinger, Jayson. Personal Interview: Austin Ramme. 25 Sept 2004. [16] Micro-Forged Metering Valves. Hoke, Inc. 15 Sept 2004. <http://www.hoke.com/pdf/1600_series.pdf>. [17] Micro Needle Valves. Scientific Instrument Services. 15 Sept 2004. <http://www.sisweb.com/catalog/?page=D64>. [18] Nanomucles. 21 Sept 2004. <http://www.nanomuscle.com/products/tech.htmL>. [19] Protein-Based Drugs: A Look Through The Crystal Ball. American Diabetes Association. 20 Sept 2004. <http://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=599>. [20] Puccinelli, John. Personal Interview: Christopher Westphal. 30 Sept 2004. [21] Pump Basics. 18 Sept 2004. <http://www.childrenwithdiabetes.com/pumps/basics.htm>. [22] P-445,P-446 Micro-Metering Valve. Western Analytical Products. 15 Sept 2004. <http://www.westernanalytical.com/upchurch/micro-metering.htm>. [23] Tight Diabetes Control. American Diabetes Association. 16 Sept 2004. <http://www.diabetes.org/type-1-diabetes/tight-control.jsp>. [24] The three skin layers: epidermis, dermis, subcutaneous fat. 18 Sept 2004. <www.pg.com/science/skincare/Skin_tws_10.htm>. [25] ZeroDraft Professional Weatherization Materials. 24 Sept 2004. <http://www.canambuildingenvelope.com/files/pdfs/330-1074.pdf>.

    18. Questions?

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