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Ageing Brain, environmental factors and metabolism

Ageing Brain, environmental factors and metabolism. Based on the Nature review: Recruiting adaptive cellular stress responses for successful brain ageing By Alexis M. Stranahan & Mark P. Mattson. Brain structures highly affected by oxidative stress.

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Ageing Brain, environmental factors and metabolism

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  1. Ageing Brain, environmental factors and metabolism Based on the Nature review: Recruiting adaptive cellular stress responses for successful brain ageing By Alexis M. Stranahan & Mark P. Mattson

  2. Brain structures highly affected by oxidative stress

  3. Neurodegenerative disorders have a logarithmic increase in prevalence with respect to aging

  4. The Selective neural vulnerability phenomena is based on morphological • -high energy requirements • -reliance on axonal support for sustained function • large cell area. • High numbers of AMPA and NMDA receptors. • Low levels of Calcium binding proteins • Dysfunction and death of neurons adversley affects both the pre- and post- synaptic neurons.

  5. Ion dysregulation via stimulation of glutamate receptors

  6. “programed” cell death

  7. Role of Mitochondria in synaptic plasticity

  8. AD oxidative damage

  9. Obesity and cognitive cognition

  10. Physical exercise and SNRI synergistic effect

  11. Beneficial molecular changes due to hormesis

  12. Phytochemicals vs. refined sugars

  13. Factors mediating Neurodegenerative disease upon aging

  14. Promoting adaptive mechanism against neurodegenerative disorders

  15. Thanks for listening

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