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Understanding Resting Membrane Potential: Ion Channels, Concentration Differences, and Nernst Equation

This text explores the concepts surrounding resting membrane potential in neural membranes, focusing on selectively permeable channels, ion concentration differences, and the Nernst relationship. It discusses the role of ion pumps and reflex loops in sensory-to-motor functions. Key topics include the structure and function of potassium channels, ion concentrations, and the Goldman equation for membrane voltage. The narrative also raises questions about the distribution of sodium and potassium ions, the implications of the potassium equilibrium potential, and the impact of oxygen deprivation on neuronal membrane potential.

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Understanding Resting Membrane Potential: Ion Channels, Concentration Differences, and Nernst Equation

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Presentation Transcript

  1. Membrane at Rest Selectively Permeable Channels Ion Concentration Differences Nernst Relationship Ion Pumps

  2. Reflex Loop: Sensory-to-Motor

  3. Water

  4. Phospholipid Bilayer

  5. Membrane is Impermeable

  6. Channels Allow Ions to Pass

  7. Protein Structure

  8. Ion Channel

  9. Potassium Channel

  10. Potassium Channel Pore

  11. Channels

  12. Ion Concentrations and Nernst Potentials

  13. Nernst Relation E = 61.54 mV log10 [ion] out/ [ion]in Lets call it 60 mV

  14. Ion Concentrations and Nernst Potentials

  15. Ion Transporters

  16. Goldman Equation Vm = 60 log10 Pk[Ko] + PNa[Nao] Pk[Kin] + PNa[Nain]

  17. Astrocytes Buffer Potassium

  18. Questions • What two functions do proteins in the neural membrane perform to establish and maintain the resting membrane potential? • ON which side of the membrane are sodium ions more abundant? • When the membrane is at the potassium equilibrium potential, in which direction (in or out) is there a net movement of potassium ions? • There is much greater concentration of potassium ions inside than outside the membrane. Why, then is the resting potential negative? • When the brain is deprived of oxygen, the mitochondria within neurons cease producing ATP. What effect would this have on the membrane potential? Why?

  19. Next Class • Chapter 4 The Action Potential

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