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Metabolism Pathways in Cysteine and Methionine Biosynthesis

This document explores the intricate metabolic pathways involved in the biosynthesis and utilization of key sulfur-containing amino acids, particularly cysteine and methionine. Notable components include homocysteine, O-acetyl-homoserine, and various enzymes such as cystathionine and methionine synthase. The role of S-adenosyl-methionine (SAM) as a methyl donor in protein and purine synthesis is highlighted. Additionally, the document discusses the importance of FeS-cluster assembly and folate derivatives in these metabolic routes.

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Metabolism Pathways in Cysteine and Methionine Biosynthesis

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  1. C C C M M M CysN cg3114 CysD cg3115 CysH cg3116 C C C M M M M Hom cg1337 CyX cg3117 CysI cg3118 Fpr2 cg3119 homoserine M MetX cg0754 C M CysK cg2833 O-acetyl-homoserine cysteine M MetB cg2687 cystathionine M MetY cg0755 AecD cg2536 homocysteine SahH cg0860 M M MetE cg1290 MetH cg1701 methionine M MetK cg1806 SO42- 3.42 / 0.48 21 / 3 / 9 3.27 / 0.78 22 / 7 / 8 2.98 / n.d. - / 1 / - aspartate--semialdehyde SO32- n.d. 1.68 / 0.22 21 / 5 / 8 3.5 / 1.08 - / - / - 3.5 / 1.06 2 / 3 / 5 2.99 / 0.25 31 / 19 / 12 S2- O-acetyl-serine 1.58 2.34 1.19 / n.d. 4 / n.d. / 1 0.42 / -0.14 120 / 106 / 93 3.71 2.46 1.34 / 0.37 39 / 19 / 34 6.96 2.43 / -0.08 97 / 29 / 41 FeS-cluster assembly -0.04 / -0.08 7 / 4 / 2 CH3-H4 folate -1.41 0.03 / 0.11 4 / 4 / 3 CH2-H4 folate 0.65 / -1.06 289 / 109 / 83 2.22 / 0.12 2 / n.d. / n.d. GDC SHMT S-adenosyl- homocysteine H4 folate 2.45 -1.09 1.29 / -0.17 7 / 5 / 2 SAM dependent methylase Protein synthesis Purine synthesis S-adenosyl-methionine n.d.

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