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Organ of Corti

Organ of Corti

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Organ of Corti

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  1. Organ of Corti

  2. Organ of Corti (limbus)

  3. Organ of Corti (tectorial memb.)

  4. Organ of Corti (inner hair cells)

  5. Organ of Corti (outer hair cells)

  6. Organ of Corti (spriral lamina)

  7. Organ of Corti (habenula perforata)

  8. Organ of Corti (supporting cells)

  9. Organ of Corti (basilar membrane)

  10. Organ of Corti (VIIIth nerve)

  11. More on Cells • Hair Cells • Outer Hair Cells • Inner Hair Cells • Supporting Cells (modiolus to stria vascularis) • Vestibular Lip • Border Cells of Held • Inner Phalangeal Cells • Rods of Corti (Pillar Cells) • Dieters Cells • Hensons Cells • Claudius and Boettcher Cells

  12. Insert zemlin page 471

  13. Cross section showing hair cells and supporting cells • Note: modiolus is to the right of slide

  14. Inner Hair Cells • Inner Hair Cells (see previous slide) • Jug shaped • Larger than OHCs • Single Row • 3000 to 4000 in number • Innervated by both afferent and efferent fibers • IHC cilia • 50 to 70 cilia per cell in U shaped configuration. • Cilia not embedded in tectorial membrane

  15. Outer Hair Cells • Outer Hair Cells (see previous slide) • Tube shaped • Smaller than IHCs • 3 rows except at apical end where it increases to 4 and then 5 rows • 12,000 to 13,000 in number • Innervated by both afferent and efferent fibers • OHC cilia • 58 cilia at apical end to 150 per cell at basal end in W or V shaped configuration. • Cilia embedded in tectorial membrane

  16. Cilia • Photo showing U shaped configuration of IHC (top) and W or V shaped configuration of OHC (bottom)

  17. Hair Cell Structures

  18. Hair Cell (stereocilia)

  19. Hair Cell (dendrite)

  20. Hair Cell (synaptic cleft)

  21. Hair Cell (cuticle)

  22. Hair Cell (reticular lamina)

  23. Hair Cell (photo) • Outer Hair cells showing the stereocilia, reticular lamina and cuticle.

  24. Hair Cell (efferent axon)

  25. Cross-section of the auditory nerve

  26. Auditory Nerve Fiber Bundle High frequency fibers: outer auditory nerve Low frequency fibers: inner auditory nerve Tonotopicity in the auditory nerve Mapping of frequency to place along the basilar membrane preserved in central auditory nervous system fiber CF 200 500 1000 Hair cells Apex: wide and loose Basilar membrane Base: narrow and tight

  27. Auditory Pathways

  28. Auditory Pathways

  29. Auditory Pathways

  30. Effects of decusation

  31. Central auditory system Structure Function/Description IHC to Auditory Nerve Fiber 1st synapse located in the cochlea Cochlear Nucleus 2nd synapse (1st central way station) Superior Olivary Complex 3rd synapse, Convergence of inputs from two ears, Delay line, localization Inferior Colliculi 4th synapse, multi-sensory integration Medial Geniculate Body 5th synapse, located in the thalamus Auditory Cortex 6th synapse

  32. Sagittal view of the brain

  33. Primary auditory cortex is tonotopically organized

  34. fiber CF 8000 Hz 4000 2000 fiber CF 200 500 1000 fiber CF 8000 Hz 4000 3000 fiber CF 200 500 700 Plasticity: flexibility, the ability to adapt to new situations. Tonotopically organized Auditory Cortex Normal Hair cell death, 1-2 kHz

  35. Central auditory pathways: review

  36. Acoustic Reflex Arc • Acoustic reflex: • Contraction of the stapedius and tensor tympani muscles occurs at high intensity levels • The response is bilateral • Some functions: • Protection from intense sounds • Smoothing of the frequency response of the outer and middle ears

  37. Acoustic Reflex Arc Midline of the brain Efferent (ipsilateral pathway) Efferent (contralateral pathway) STIMULUS Afferent

  38. Inner Ear Fluids

  39. Blood Supply

  40. Summary