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PCSK9 Inhibition for Lp(a) Reduction: Dosing Schemes and Efficacy Study

Study on Lp(a) reduction after different dosing schemes of PCSK9 inhibitor AMG 145 at various doses over 12 weeks. Significant reduction observed compared to placebo. Research by Desai et al. published in Circulation, July 2013.

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PCSK9 Inhibition for Lp(a) Reduction: Dosing Schemes and Efficacy Study

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  1. Lp(a) reductionafter different dosingschemes of PCSK9 inhibition AMG 145 Q2W AMG 145 Q4W 0 70mg (n=75) 105mg (n=76) 140mg (n=73) 280mg (n=78) 350mg (n=79) 420mg (n=77) -10 -18.2 -18.0 LS Mean % change in Lp(a) from baseline to week 12 -20 -22.8 -23.1 -18 -30 -32.1 -32.3 -40 P<0.001 foreachdose vs. placebo P<0.001 foreachdose vs. placebo Desaiet al.Circulation 2013 July 24

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