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microangiopathic hemolytic anemia

microangiopathic hemolytic anemia. microangiopathic hemolytic anemia. TTP. reticulocytes. Polychromasia. Autoimmune hemolytic anemia. Target Cells. Increased surface to volume ratio Actually shaped like a bell (3D) Target cells are always hypochromic

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microangiopathic hemolytic anemia

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  1. microangiopathic hemolytic anemia

  2. microangiopathic hemolytic anemia

  3. TTP

  4. reticulocytes

  5. Polychromasia

  6. Autoimmune hemolytic anemia

  7. Target Cells • Increased surface to volume ratio • Actually shaped like a bell (3D) • Target cells are always hypochromic • Excess membrane cholesterol and phospholipid • Decreased osmotic fragility

  8. Target Cells • Hemoglobin C disease • Liver disease • Iron deficiency • Any hemoglobin abnormality • Post splenectomy

  9. Target Cells (Codocytes)

  10. Target Cells

  11. 10 y/o boy of Italian descent Diagnosis : Beta thalassemia major Homozygous beta0 thalassemia Comment : beta0 = beta gene producing no beta chains no beta chains and hence no Hb A. untreated he has about 95% Hb F (remainder being Hb A2) Treatment : Transfusion to maintain hemoglobin level; Chelation therapy to remove excess iron present due to hemolysis and transfusions. Bone marrow transplantation is treatment of choice

  12. Case 2 Sickle cell Howell Jolly Body Erythroblast

  13. Sickle cells (Drepanocytes)

  14. Sickle Cells

  15. Sickle Cells

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