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Magnetically-Guided Nanoparticles for Targeted Drug Delivery

Magnetically-Guided Nanoparticles for Targeted Drug Delivery. Presentation for RET program June 30, 2011 Seth Baker Advisors: Dr. Andreas Linninger Eric Lueshen, Madhawa Hettiarachchi Laboratory for Product and Process Design University of Illinois- Chicago

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Magnetically-Guided Nanoparticles for Targeted Drug Delivery

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  1. Magnetically-Guided Nanoparticles for Targeted Drug Delivery Presentation for RET program June 30, 2011 Seth Baker Advisors: Dr. Andreas Linninger Eric Lueshen, Madhawa Hettiarachchi Laboratory for Product and Process Design University of Illinois- Chicago Department of Chemical Engineering University of Illinois Chicago, LPPD, Summer 2011

  2. Motivations for Research • Over 7 million Americans suffer from neurological conditions such as Alzheimer’s, Parkinson’s, Brain Cancer, and Stroke. • These conditions have direct and indirect costs of over $200 billion dollars annually in the United States. • Magnetically-guided nanoparticle drug delivery allows treatment for • Neurological diseases such as Alzheimer’s and Parkinson’s • Abnormal vascular structures (tumors) • Stroke conditions • Effective methods of blocking angiogenesis of tumors University of Illinois Chicago, LPPD, Summer 2011

  3. Materials for Research Magnetite core (Fe3O4) nanoparticles from 8 – 30 nm in diameter. Nanoparticles are defined as less than 100 nm diameter and can pass through endothelial barriers. Prussian blue stain for imaging the movement of the magnetic (iron) nanoparticles. Agarose gel brain phantoms with similar properties to brain tissue. University of Illinois Chicago, LPPD, Summer 2011

  4. Benefits of Magnetic Nanoparticles • Allows for more targeted drug delivery resulting in lower dosage and systemic toxicity. • Magnetite core nanoparticles are biocompatible and biodegradable. • Nanoparticles can be coated or loaded with various therapeutics. Magnetically-guided nanoparticles for targeted drug delivery can provide a wide range of applications for the detection, diagnosis and treatment of neurological conditions. University of Illinois Chicago, LPPD, Summer 2011

  5. Experimental Design • Agarose Gel Experiments • Agarose Gel Experiments • Rat Brain Staining Investigating 35 and 173 pound magnetic pull force on magnetite nanoparticles in 5% agarose gel. Infusion flow rate is 0.5 µl/min. Investigating the movement of Prussian Blue stain in rat brain samples to determine permeability of brain tissue. University of Illinois Chicago, LPPD, Summer 2011

  6. Future Work • Measure magnetic nanoparticle movement in different concentrations of agarose gel and magnetic force. • Determine best method for visualizing the nanoparticle movement (Prussian blue stain, angiogram) • Determine the most effective protocol for administrating and measuring magnetically-guided nanoparticles in rat brain samples. • Investigate methods to manufacture nanoparticles University of Illinois Chicago, LPPD, Summer 2011

  7. Acknowledgements • NSF EEC-0502272 Grant, Chicago Science Teacher Research • Dr. Andreas Linninger • Eric Lueshen • Sukhi Basati • Joe Kanikunnel – REU Summer Fellow University of Illinois Chicago, LPPD, Summer 2011

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