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Development of Portable Digital Microfluidics for Point-of-Care Medical Testing

This project addresses the need for affordable and portable point-of-care medical testing devices, especially in restricted access areas like remote locales and battlefields. Digital microfluidics utilizes an array of electrodes that employ the electrowetting effect to manipulate liquid droplets, enabling automated biological protocols in a miniaturized format. While lab-on-a-chip devices offer promising capabilities, commercially viable solutions are still in development. This initiative aims to meet customer requirements and enhance understanding of digital microfluidic technologies.

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Development of Portable Digital Microfluidics for Point-of-Care Medical Testing

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  1. Group R14300 – Digital Microfluidics Peter DunningPaulina Klimkiewicz Matthew Partacz Andrew Greeley Thomas Wossner WunnaKyaw

  2. Motivation • Need for point of care medical testing devices where access to conventional tests is restricted • Ex: Doctor’s Offices, Remote Areas, Battlefields • A solution must be portable and cheap http://gdb.voanews.com/6C27D536-9955-4670-91C4-101E2D5A6322_w640_r1_s.jpg

  3. Background • Lab-on-a-chip devices are capable of miniaturizing and automating biological protocols. • Devices suited for commercial use have yet to be developed. http://2.imimg.com/data2/GK/EX/MY-920622/micro-biological-testing-250x250.jpg http://www.lionixbv.nl/technology/technology-microfluidics.html

  4. Microfluidic Platforms Major microfluidic platforms organized by liquid actuation [1]

  5. Digital MicroFluidic devices • Array of electrodes which use the electrowetting effect to manipulate droplets. Cross-section view of Digital Microfluidic device. Dotted line indicates the shape of the meniscus before actuation. Modified from [2] “The electrowetting effect (in air)” [3] “Top view of flow on a ring structure” [3]

  6. Customer Requirements

  7. Customer Requirement Cont.

  8. Outstanding VOC • We will be meeting with Dr. Schertzer in the near future to confirm these requirements. • Questions for Audience • Are our goals for this project clearly defined? • Do you have some understanding of how Digital Microfluidic Devices work?

  9. References • [1] Mark, D., Haeberle, S., Roth, G., Von Stetten, F., and Zengerle, R., 2010, "Microfluidic Lab-on-a-Chip Platforms: Requirements, Characteristics and Applications," Chemical Society Reviews, 39(3), pp. 1153-1182. • [2] Cho, S. K., Moon, H. J., and Kim, C. J., 2003, "Creating, Transporting, Cutting, and Merging Liquid Droplets by Electrowetting-Based Actuation for Digital Microfluidic Circuits," Journal of Microelectromechanical Systems, 12(1), pp. 70-80. • [3] Fair, R., The Electrowetting Effect (in Air), February 1, http://microfluidics.ee.duke.edu/

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