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Compounds of Interest. ProteinsPolymers of Amino AcidsNucleic AcidsPolymers of NucleotidesRibosugar, phosphate, and nitrogenous baseAlkaloidsAminocarbohydratesPolymers containing glycosamines. Methods for Synthesizing a Carbon-Nitrogen Bond. Amines via nucleophilic substitutionAlkyl halide
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1. Naturally Occurring Nitrogen-Containing Compounds Chapter 18
Chemistry 224
Bunde Spring 2009
2. Compounds of Interest Proteins
Polymers of Amino Acids
Nucleic Acids
Polymers of Nucleotides
Ribosugar, phosphate, and nitrogenous base
Alkaloids
Aminocarbohydrates
Polymers containing glycosamines
3. Methods for Synthesizing a Carbon-Nitrogen Bond Amines via nucleophilic substitution
Alkyl halide + ammonia (alkyl amine)
Amines from the reduction of amides
Acid chloride + ammonia, reduction with LiAlH4
Amines from the reduction of imines
Ketone + amine, followed with NaBH4 or H2
Nucleophilic addition to imines
Mannich Condensation
Amines from Nitrile reduction
Amines from Beckman Rearrangement of Oximes