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BIOSINTESI DELLE CATECOLAMINE

BIOSINTESI DELLE CATECOLAMINE. AZIONI PERIFERICHE DELLA DOPAMINA. Recettori D1 (distretti vascolari renale, mesenterico e coronarico). Vasodilatazione;  RBF, GFR e secrezione di Na+. Recettori 1 (cardiaci). Effetto inotropo e cronotropo +. MALATTIA DI PARKINSON. Segni cardinali

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BIOSINTESI DELLE CATECOLAMINE

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  1. BIOSINTESI DELLE CATECOLAMINE

  2. AZIONI PERIFERICHE DELLA DOPAMINA Recettori D1 (distretti vascolari renale, mesenterico e coronarico) Vasodilatazione;  RBF, GFR e secrezione di Na+ Recettori 1 (cardiaci) Effetto inotropo e cronotropo +

  3. MALATTIA DI PARKINSON • Segni cardinali • Bradicinesia • Rigidità muscolare • Tremore a riposo • Deficit dell’equilibrio posturale

  4. MALATTIA DI PARKINSON

  5. DDC DDC MAO MAO COMT COMT Tratto GI Sangue e tessuti periferici Cervello 1% LEVODOPA 9% 90%

  6. selegiline X X tolcapone

  7. 1 1 3 2 4 2 + -

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