1 / 9

Tcoffee@igs: a web server for computing, evaluating and combining multiple sequence alignments

Tcoffee@igs: a web server for computing, evaluating and combining multiple sequence alignments. Olivier Poirot, Eamonn O'Toole and Cedric Notredame Nucleic Acids Research, 31, 3503-3506 (2003) July 22, 2003 Park, Ji-Yoon. Abstract. Tcoffee@igs

robbin
Télécharger la présentation

Tcoffee@igs: a web server for computing, evaluating and combining multiple sequence alignments

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Tcoffee@igs: a web server for computing, evaluating and combining multiple sequence alignments Olivier Poirot, Eamonn O'Toole and Cedric Notredame Nucleic Acids Research, 31, 3503-3506 (2003)July 22, 2003 Park, Ji-Yoon

  2. Abstract • Tcoffee@igs • Web-based tool to the computation, the evaluation & combination of multiple alignment • The latest version of the T-Coffee package • Provided by Hewlet Packard & Centre National de la Recherche Scientifique • Can be used for align protein, RNA or DNA • 100 sequences (2,000 residues long) process available

  3. Related Publication • T-Coffee: A novel method for multiple sequence alignments.C.Notredame, D. Higgins, J. Heringa,Journal of Molecular Biology,Vol 302, pp205-217,2000 [pdf] • COFFEE: A New Objective Function For Multiple Sequence Alignmnent.C. Notredame, L. Holme and D.G. Higgins, Bioinformatics,Vol 14 (5) 407-422,1998 [pdf]

  4. http://igs-server.cnrs-mrs.fr/

  5. Tcoffee

  6. Methods • Multiple sequence alignment assembly- Given a set of pre-selected protein or DNA seq, computes a multiple seq alignment of the input sequences- By computing a collection of pair-wise alignment [ the best global alignment & 10 best local alignment ]- The highest level of consistency with alignment within the library • Computing a multiple alignment - FASTA form sequence • Evaluating a multiple alignment - evaluate pre-computed multiple sequence alignment IV. Combine multiple alignments

  7. Output of T-Coffee Computation

  8. Colored Output of T-Coffee

  9. Conclusion & Future Developments • Tcoffee@igs • A new multiple sequence alignment server • To produce high quality multiple sequence alignment • Further development - Enhanced regarding the mixing of sequences & structure

More Related