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Probiotics May Lower Risk for Nosocomial Infections in Hospitalized Children

Probiotics May Lower Risk for Nosocomial Infections in Hospitalized Children. A randomized, double-blind, placebo-controlled trial reported in the May issue of Pediatrics . 2010. Children ‘s Hospital 2 – Infection Control Department. BACKGROUNDS.

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Probiotics May Lower Risk for Nosocomial Infections in Hospitalized Children

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  1. Probiotics May Lower Risk for Nosocomial Infections in Hospitalized Children A randomized, double-blind, placebo-controlled trial reported in the May issue of Pediatrics. 2010 Children ‘s Hospital 2 – Infection Control Department

  2. BACKGROUNDS • The incidence of nosocomial infections, predominantly gastrointestinal and respiratory, in children in developed countries is high, ranging from 5% to 44%. • Gastrointestinal infections (4.5–22.6 episodes per 100 admissions) and respiratory infections (incidence ranging from 13% to 53% in all hospitalized children) account for the predominant types of infections.

  3. BACKGROUNDS • One of the potential strategies for the prevention of nosocomial infections is the use of probiotics. The objective of this study was to investigate the role of Lactobacillus GG (LGG) in preventing nosocomial gastrointestinal and respiratory tract infections at a pediatric hospital.

  4. METHODS • The study design was a prospective, randomized, double-blind, placebo-controlled trial. • 742 children, aged 1 to 18 years, were randomly assigned to receive LGG (n = 376) or placebo (n = 366) during their hospitalization at Pediatric Department (Children's Hospital Zagreb, Zagreb, Croatia) from November 2007 to May 2008.

  5. METHODS • LGG was given at a dose of 109 colony-forming units in 100 mL of a fermented milk product, and the placebo consisted of the same postpasteurized fermented milk product without LGG. • The LGG product and placebo were packed in identical bottles; they were of the same color, weight, smell, and taste.

  6. METHODS • During the test period, patients were not allowed to consume any other product that contained probiotics or prebiotics. • All gastrointestinal and respiratory tract infections were diagnosed by a pediatrician.

  7. RESULTS • The risk for gastrointestinal infections was significantly reduced in the LGG group compared with the placebo group (RR: 0.40 [95% CI: 0.25 –0.70]; NNT: 15 [95% CI: 9–34]). • Similarly, the risk for respiratory tract infections was significantly reduced in the LGG group compared with the placebo group (RR: 0.38 [95% CI: 0.18–0.85]; NNT: 30 [95% CI: 16–159]).

  8. RESULTS • Moreover, in gastrointestinal infections patients, they compared the LGG group with the placebo group, children in the LGG group had a reduced risk for vomiting episodes (RR: 0.5 [95% CI: 0.3–0.9]) and diarrheal episodes (RR: 0.24 [95% CI: 0.10–0.50].

  9. RESULTS • None of the gastrointestinal infection patients had a bacterial infection. • In 5 patients, rotavirus (2 patients: both in the placebo group) or norovirus (3 patients: 2 in the placebo group and 1 in the LGG group) was isolated. All patients were treated symptomatically, and none required antibiotic treatment.

  10. RESULTS • In regard to respiratory tract infections, patients in the LGG group had a lower risk for episodes of respiratory tract infections that lasted >3 days than patients in the placebo group (RR: 0.4 [95% CI: 0.2–0.9]; NNT: 33 [95% CI: 17–257])

  11. RESULTS • All patients had upper respiratory tract infections, and only 1 patient in the placebo group also had a diagnosis of pneumonia. • A bacterial cause was determined and treated with antibiotics in only 5 patients with upper respiratory tract infections (4 were from the placebo group).

  12. CONCLUSIONS • The results of the randomized, double-blind, placebo-controlled trial suggests that Lactobacillus GG administration decreases the risk for nosocomial gastrointestinal and respiratory tract infections in hospitalized children.  LGG administration can be recommended as a valid measure for decreasing the risk for nosocomial gastrointestinal and respiratory tract infections in pediatric facilities.

  13. CONCLUSIONS • However, they suggest that this may not be justified in all hospitalized children because of the relatively high NNT (15 for gastrointestinal tract infections and 30 for respiratory tract infections).

  14. CONCLUSIONS • Limitations of the study include exclusion of infants younger than 1 year, and short duration and unproven cause of most of the nosocomial infections diagnosed during the study.  They encourage future studies of children who are younger than 12 months.

  15. THANK YOU

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